Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae
Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae
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DOI：
10.1016/s1471-4906(01)01926-3
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发表时间：
2001-06-01
影响因子：
16.8
通讯作者：
Wu, ZQ
中科院分区：
文献类型：
--
作者：
Snapper, CM;Shen, Y;Wu, ZQ
研究表明，纯化的可溶性多糖抗原可以在体内引起T细胞非依赖性IG应答，尽管这些应答可以由T细胞以非同源方式调节。然而，关于调节多糖特异性的参数，相对知之甚少。以及对完整的细胞外细菌的蛋白特异性IG同种型应答。使用鼠对完整肺炎链球菌的体内体液应答作为模型，可以表明CD4（+）T细胞受体α β（+）T细胞为多糖特异性和蛋白特异性IG应答提供帮助。然而，这些反应在其作用机制上有根本的不同。
Studies have indicated that purified soluble polysaccharide antigens can elicit T cell-independent Ig responses in vivo, although these responses can be modulated by T cells in a noncognate manner. Relatively little is known, however, concerning the parameters that regulate polysaccharide-specific. as well as protein-specific, Ig isotype responses to an intact extracellular bacterium. Using the murine in vivo humoral response to intact Streptococcus pneumoniae as a model it can be shown that CD4(+) T-cell receptor alpha beta (+) T cells deliver help for both polysaccharide- and protein-specific Ig responses. However, these responses differ fundamentally in their mechanism of action.