Baroreflex control of renal sympathetic nerve activity during air-jet stress in rats
Baroreflex control of renal sympathetic nerve activity during air-jet stress in rats
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DOI：
10.1152/ajpregu.00413.2006
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发表时间：
2007-01-01
影响因子：
2.8
通讯作者：
Julien, Claude
中科院分区：
文献类型：
--
作者：
Kanbar, Roy;Orea, Valerie;Julien, Claude
急性情绪应激对动脉压力感受器反射的交感成分的影响尚未在有意识的动物和人类中描述。在11只清醒大鼠暴露于轻度环境应激（空气）前和暴露过程中，同时记录动脉压（AP）和肾交感神经活动（RSNA）。压力反射功能曲线相关AP和RSNA通过拟合一个S形函数的RSNA和AP在连续硝普钠和苯乙醯胺管理。应激使平均AP从112 +/- 2增加到124 +/- 2 mmHg，心率从381 +/- 10增加到438 +/- 18次/分，RSNA从0.80 +/- 0.14增加到1.49 +/- 0.23 μ V。RSNA-AP关系向更高的AP值移动，其最大增益从9.0 ± 1.3增加到16.2 ± 2.1标准化单位（NU）/mmHg（P < 0.01）。后一种效应继发于RSNA变异范围从285 +/- 33到619 +/- 59 NU的增加（P < 0.01）。此外，反射的操作范围从34 +/- 2增加到41 +/- 3 mmHg（P < 0.01）。目前的研究表明，在大鼠中，RSNA的压力感受性反射控制是敏感的，并在更大的范围内操作在情绪应激，这表明，肾血管紧张度，并可能AP，是非常有效地控制交感神经系统在这种情况下。
The effects of acute emotional stress on the sympathetic component of the arterial baroreceptor reflex have not yet been described in conscious animals and humans. Arterial pressure (AP) and renal sympathetic nerve activity (RSNA) were simultaneously recorded in 11 conscious rats before and during exposure to a mild environmental stressor (et of air). Baroreflex function curves relating AP and RSNA were constructed by fitting a sigmoid function to RSNA and AP measured during sequential nitroprusside and phenylephrine administrations. Stress increased mean AP from 112 +/- 2 to 124 +/- 2 mmHg, heart rate from 381 +/- 10 to 438 +/- 18 beats/min, and RSNA from 0.80 +/- 0.14 to 1.49 +/- 0.23 mu V. The RSNA-AP relationship was shifted toward higher AP values, and its maximum gain was significantly (P < 0.01) increased from 9.0 +/- 1.3 to 16.2 +/- 2.1 normalized units (NU)/mmHg. The latter effect was secondary to an increase (P < 0.01) in the range of the RSNA variation from 285 +/- 33 to 619 +/- 59 NU. In addition, the operating range of the reflex was increased (P < 0.01) from 34 +/- 2 to 41 +/- 3 mmHg. The present study indicates that in rats, the baroreflex control of RSNA is sensitized and operates over a larger range during emotional stress, which suggests that renal vascular tone, and possibly AP, are very efficiently controlled by the sympathetic nervous system under this condition.