The Parkinson's disease sleep scale:: a new instrument for assessing sleep and nocturnal disability in Parkinson's disease
The Parkinson's disease sleep scale:: a new instrument for assessing sleep and nocturnal disability in Parkinson's disease
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DOI：
10.1136/jnnp.73.6.629
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发表时间：
2002-12-01
影响因子：
11
通讯作者：
Trenkwalder, C
中科院分区：
文献类型：
--
作者：
Chaudhuri, KR;Pal, S;Trenkwalder, C
背景：没有正式的工具可用于量化帕金森病的睡眠问题。目的：开发一种新的睡眠量表来量化帕金森病夜间睡眠问题的各个方面，帕金森病可能发生在高达96%的患者中。方法：采用多学科团队的方法，设计了一种视觉模拟量表，用于解决帕金森病中与睡眠障碍相关的15种常见症状-帕金森病睡眠量表（PDSS）。总共有143名帕金森病患者完成了PDSS，涵盖了从新诊断到晚期的整个疾病范围。作为对照，137名年龄匹配的健康受试者也完成了量表。在一组受试者中评估重测信度。103名帕金森病患者也满意地完成了Epworth嗜睡量表。结果：帕金森组的PDSS评分与健康对照组有显著差异。与早期/中度帕金森病患者相比，晚期帕金森病患者得分较低。量表的单项在帕金森病患者和健康对照者之间显示出良好的区分力。PDSS的相关项目与白天过度嗜睡相关。量表具有良好的重测信度。结论：这似乎是对帕金森病睡眠障碍评估的简单床边筛查仪器的首次描述。子项目的组合可能有助于识别睡眠障碍的具体方面，从而有助于有针对性的治疗。
Background: No formal instruments are available for quantifying sleep problems in Parkinson's disease.Objective: To develop a new sleep scale to quantify the various aspects of nocturnal sleep problems in Parkinson's disease, which may occur in up to 96% of affected individuals.Methods: Employing a multidisciplinary team approach, a visual analogue scale was devised addressing 15 commonly reported symptoms associated with sleep disturbance in Parkinson's disease-the Parkinson's disease sleep scale (PDSS). In all, 143 patients with Parkinson's disease completed the PDSS, covering the entire spectrum of disease from newly diagnosed to advanced stage. As controls, 137 age healthy matched subjects also completed the scale. Test-retest reliability was assessed in a subgroup of subjects. The Epworth sleepiness scale was also satisfactorily completed by 103 of the patients with Parkinson's disease.Results: PDSS scores in the Parkinson group were significantly different from the healthy controls. Patients with advanced Parkinson's disease had impaired scores compared with early/moderate disease. Individual items of the scale showed good discriminatory power between Parkinson's disease and healthy controls. Relevant items of the PDSS correlated with excessive daytime sleepiness. The scale showed robust test-retest reliability.Conclusions: This appears to be the first description of a simple bedside screening instrument for evaluation of sleep disturbances in Parkinson's disease. A combination of subitems may help identify specific aspects of sleep disturbance, which in turn may help target treatment.