Dissecting the mode of action of a neuronal growth factor.
Dissecting the mode of action of a neuronal growth factor.
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DOI：
10.1007/978-3-642-75747-1_7
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发表时间：
1991
影响因子：
--
通讯作者：
S. Halegoua;R. Armstrong;N. E. Kremer
中科院分区：
文献类型：
--
作者：
S. Halegoua;R. Armstrong;N. E. Kremer
神经生长因子（NGF）和成纤维细胞生长因子（FGF）在外周和中枢神经系统的发育中起重要作用。这些试剂是体内和神经元细胞培养物中的存活因子。它们似乎促进不同类别神经元的分化，并且还可能在神经元突起生长的指导中发挥一定作用。很明显，神经元生长因子，如NGF和FGF，包括一个巨大的范围内的行动，阐明潜在的分子机制是一项艰巨的任务。然而，一个多学科的方法已经带来了承担这一任务，和神经生长因子的行动的研究已经获得了以及贡献的见解，其他领域。
The neuronal growth factors nerve growth-factor (NGF) and fibroblast growth factor (FGF) play important roles in the development of both the peripheral and central nervous systems. These agents are survival factors in vivo and in neuronal cell culture. They appear to promote the differentiation of different classes of neurons and may also play some part in the guidance of neuronal process outgrowth. It is apparent that neuronal growth factors, as exemplified by NGF and FGF, encompass an enormous range of actions, making elucidation of the underlying molecular mechanisms a formidable task. However, a multidisciplinary approach has been brought to bear on this task, and studies of neuronal growth factor action have gained from as well as contributed insights to other fields.