Platinum on carbon-catalysed site-selective H-D exchange reaction of allylic alcohols using alkyl amines as a hydrogen source
Platinum on carbon-catalysed site-selective H-D exchange reaction of allylic alcohols using alkyl amines as a hydrogen source
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使用烷基胺作为氢源的碳催化烯丙醇位点选择性 H-D 交换反应中的铂
DOI：
10.1039/d2qo00177b
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Hironao Sajiki
中科院分区：
文献类型：
--
作者：
Kwihwan Park;Naoki Oka;Yoshinari Sawama;Takashi Ikawa;Tsuyoshi Yamada;Hironao Sajiki
以氧化氘为氘源，发展了碳载铂催化的叔烯丙醇氘代反应。戊胺在铂碳催化剂上脱氢生成适量氢气，有效地促进了H-D交换反应。各种烯丙醇的位置选择性氘代具有良好至优异的氘含量，而不氢化的烯烃官能度。得到的氘标记的烯丙醇进一步转化成各种氘标记的建筑单元，而不降解的原始氘含量。
We developed a platinum on carbon-catalysed deuteration reaction of tert-allylic alcohols using deuterium oxide as a deuterium source. Amylamine was dehydrogenated by platinum on carbon to generate an appropriate amount of hydrogen gas, which efficiently promoted the H–D exchange reaction. Various allylic alcohols were site-selectively deuterated with good to excellent deuterium contents without hydrogenation of the alkene functionality. The obtained deuterium-labelled allylic alcohols were further transformed into various deuterium-labelled building blocks without degradation of the original deuterium content.