Macrocyclic Polyamine Complex Beyond Metalloenzyme Models
Macrocyclic Polyamine Complex Beyond Metalloenzyme Models
复制标题
超越金属酶模型的大环多胺复合物
DOI：
10.1007/978-94-015-8380-0_13
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
M. Shionoya
中科院分区：
文献类型：
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作者：
E. Kimura;M. Shionoya
随着大环多胺锌（II）配合物的出现，锌（II）酶模型取得了新的突破。这些复合物作为锌（II）酶活性中心的最佳结构和功能模型（例如，碳酸酐酶、碱性磷酸酶和乙醇脱氢酶），并清楚地回答了围绕锌（II）酶中锌（II）内在性质的谜团。关于锌（II）性质的知识已发展成为超分子化学的一个新方面，其中锌（II）酶模型复合物可以识别所有核碱基中的胸腺嘧啶及其相关衍生物。此外，这种超分子化学可以应用于涉及基因表达的生物化学过程。
A new breakthrough for zinc(II) enzyme models has been achieved with the advent of macrocyclic polyamine zinc(II) complexes. These complexes serve as both the best structural and functional models for the active centers of zinc(II) enzymes (e.g., carbonic anhydrase, alkaline phosphatase, and alcohol dehydrogenase) and have clearly answered mysteries that surround the intrinsic properties of zinc(II) in zinc(II) enzymes. The knowledge gained about the properties of zinc(II) has been developed into a new aspect of supramolecular chemistry, where zinc(II) enzyme model complexes can recognize thymine and its related derivatives among all the nucleobases. Furthermore, this supmmolecular chemistry can be applied to biochemical processes involving gene expression.