The SaPIs: mobile pathogenicity islands of Staphylococcus.
The SaPIs: mobile pathogenicity islands of Staphylococcus.
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DOI：
10.1159/000100857
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Subedi, Abhignya
中科院分区：
文献类型：
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作者：
Novick, Richard P;Subedi, Abhignya
SaPI是葡萄球菌中15- 17 kb的移动的致病岛。它们通常携带两种或更多种超抗原，并导致大多数超抗原相关的人类疾病，尤其是葡萄球菌中毒性休克综合征。SaPI在金黄色葡萄球菌中非常常见，除了一个测序的基因组外，所有基因组都含有一个或多个SaPI。SaPI具有高度保守的整体基因组组织，与典型的温带植物相似。每一个都占据一个特定的染色体位点，从那里它被一个或多个特定的葡萄球菌诱导切除和复制。复制后，SaPI DNA被有效地复制成感染性的小头噬菌体样颗粒，导致极高的转移频率。
The SaPIs are 15- to 17-kb mobile pathogenicity islands in staphylococci. They usually carry two or more superantigens and are responsible for most superantigen-related human diseases, especially staphylococcal toxic shock syndrome. SaPIs are extremely common in Staphylococcus aureus, with all but one of the sequenced genomes containing one or more. The SaPIs have a highly conserved overall genome organization, parallel to that of typical temperate phages. Each occupies a specific chromosomal site from which it is induced to excise and replicate by one or more specific staphylococcal phages. Following replication, the SaPI DNA is efficiently encapsidated into infectious small-headed phage-like particles, resulting in extremely high transfer frequencies.