Automatic quantification of ejection fraction from gated myocardial perfusion SPECT.

Automatic quantification of ejection fraction from gated myocardial perfusion SPECT.
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发表时间：
1995-11
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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通讯作者：
G. Germano;H. Kiat;P. Kavanagh;M. Moriel;M. Mazzanti;H. Su;K. V. Train;D. Berman
G. Germano;H. Kiat;P. Kavanagh;M. Moriel;M. Mazzanti;H. Su;K. V. Train;D. Berman
中科院分区：
其他
文献类型：
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作者：
G. Germano;H. Kiat;P. Kavanagh;M. Moriel;M. Mazzanti;H. Su;K. V. Train;D. Berman

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未标记 我们开发了一种全自动算法，可通过门控 99mTc-sestamibi 心肌灌注 SPECT 图像定量测量左心室射血分数 (LVEF)。方法 该算法在三维空间中运行并使用门控短轴图像体积。它对左心室 (LV) 进行分段，估计并显示心动周期中所有门控间隔的心内膜和心外膜表面，计算相对左心室腔容积，并从舒张末期和收缩末期容积导出全局 EF，所有这些都无需操作员交互。用于测量 LVEF 的算法在 65 名接受 16 间隔和 8 间隔休息门控 SPECT 的临床患者中进行了测试，并针对首过放射性核素心室造影进行了验证。结果 65/65 (100%) 的研究中 LV 自动分割和轮廓绘制是成功的。 8 间隔门控 SPECT 测量的 EF 与首次通过数据计算的 EF 之间的一致性很高（y = 2.44 + 1.03x，r = 0.909，p < 0.001，s.e.e. = 6.87）。 16 间隔和 8 间隔门控 SPECT 测量的 EF 值之间的一致性非常好（y = -2.7 + 0.97x，r = 0.988，p < 0.001，s.e.e. = 2.65），后者平均低 3.71 个百分点。结论 我们的自动方法快速且与 EF 的传统放射性核素测量高度一致，从而提供临床上有用的附加信息来补充心肌灌注研究。
UNLABELLED We have developed a completely automatic algorithm to quantitatively measure left ventricular ejection fraction (LVEF) from gated 99mTc-sestamibi myocardial perfusion SPECT images. METHODS The algorithm operates in the three-dimensional space and uses gated short-axis image volumes. It segments the left ventricle (LV), estimates and displays endocardial and epicardial surfaces for all gating intervals in the cardiac cycle, calculates the relative left ventricular cavity volumes and derives the global EF from the end-diastolic and end-systolic volume, all without operator interaction. The algorithm for measuring LVEF was tested in 65 clinical patients undergoing 16-interval and 8-interval rest-gated SPECT and validated against first-pass radionuclide ventriculography. RESULTS Automatic segmentation and contouring of the LV was successful in 65/65 (100%) of the studies. Agreement between EFs measured from 8-interval gated SPECT and EFs calculated from first-pass data was high (y = 2.44 + 1.03x, r = 0.909, p < 0.001, s.e.e. = 6.87). Agreement between EF values measured from 16-interval and 8-interval gated SPECT was excellent (y = -2.7 + 0.97x, r = 0.988, p < 0.001, s.e.e. = 2.65), the latter being on average lower by 3.71 percentage points. CONCLUSION Our automatic method is rapid and highly agrees with conventional radionuclide measurements of EF, thus providing clinically useful additional information to complement myocardial perfusion studies.