Maternal arsenic exposure associated with low birth weight in Bangladesh
Maternal arsenic exposure associated with low birth weight in Bangladesh
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DOI：
10.1097/jom.0b013e3181566ba0
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发表时间：
2007-10-01
影响因子：
3.2
通讯作者：
Christiani, David C.
中科院分区：
文献类型：
--
作者：
Huyck, Karen L.;Kile, Molly L.;Christiani, David C.
目的：探讨砷暴露对新生儿出生体重的影响。研究方法：在怀孕期间的多个时间点从孕妇（n = 52）和出生后的新生儿中收集头发，脚趾甲和饮用水样本。总砷采用电感耦合等离子体质谱法测定。砷和出生体重之间的关联进行了研究，采用线性和逻辑回归模型。结果：母亲在怀孕早期头发砷测量与出生体重下降（β =-193.5 +/- 90.0 g，P = 0.04）。首次产前检查时母亲头发和饮用水砷水平与新生儿头发砷水平显著相关（β = 0.32，P = 0.04和β = 0.31，P = 0.04）。结论：结果表明，母亲砷暴露在怀孕早期对新生儿出生体重产生负面影响，母亲的头发提供了最好的综合措施砷暴露。
Objective: To characterize the effects of maternal arsenic exposure on birth weight. Methods: Hair, toenail, and drinking water samples were collected from pregnant women (n = 52) at multiple time points during pregnancy and from their newborns after birth. Total arsenic was measured using inductively coupled plasma-mass spectrometry. The association between arsenic and birth weight was investigated using linear and logistic regression models. Results: Maternal hair arsenic measured early in pregnancy was associated with decreased birth weight (beta = - 193.5 +/- 90.0 g, P = 0.04). Maternal hair and drinking water arsenic levels measured at first prenatal visit were significantly correlated with newborn hair arsenic level (beta = 0.32, P = 0.04 and beta = 0.31, P = 0.04). Conclusions: Results suggest that maternal arsenic exposure early in pregnancy negatively affects newborn birth weight and that maternal hair provides the best integrated measure of arsenic exposure.