Old and new pathways of protein export in chloroplasts and bacteria
Old and new pathways of protein export in chloroplasts and bacteria
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DOI：
10.1016/s0962-8924(98)01387-7
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发表时间：
1998-12-01
影响因子：
19
通讯作者：
Martienssen, R
中科院分区：
文献类型：
--
作者：
Settles, AM;Martienssen, R
叶绿体蛋白质靶向类囊体膜类似于细菌的分泌，我们所知道的很多都是从大肠杆菌的分泌机制中了解到的。然而，叶绿体也使用Delta pH依赖性途径来靶向类囊体蛋白，其中至少一些在运输之前折叠。以前，该途径似乎在细菌中没有同源物，但最近的结果表明，玉米中的HCF106基因编码该途径的一个组分，并且具有细菌同源物。这种依赖于Δ pH值的途径可能是一种古老的保守的蛋白质转运机制，在质体和线粒体的内共生起源之前就已经进化了。
Targeting of chloroplast proteins to the thylakoid membrane is analogous to bacterial secretion, and much of what we know has been learned from secretory mechanisms in Escherichia coli. However, chloroplasts also use a Delta pH-dependent pathway to target thylakoid proteins, at least some of which are folded before transport Previously, this pathway seemed to have no cognate in bacteria, but recent results have shown that the HCF106 gene in maize encodes a component of this pathway and has bacterial homologues. This Delta pH-dependent pathway might be an ancient conserved mechanism for protein translocation that evolved before the endosymbiotic origin of plastids and mitochondria.