Detection of human coronavirus NL63 in young children with bronchiolitis
Detection of human coronavirus NL63 in young children with bronchiolitis
复制标题
DOI：
10.1002/jmv.20289
复制
发表时间：
2005-03-01
影响因子：
12.7
通讯作者：
Kikuta, H
中科院分区：
文献类型：
--
作者：
Ebihara, T;Endo, R;Kikuta, H
HCoV-NL 63是第四种人类冠状病毒，最近已从呼吸道感染的儿童中分离出来，包括上呼吸道感染，细支气管炎和肺炎。在患有呼吸道感染的免疫功能低下的成人中也检测到该病毒。共选择了118例未感染人呼吸道合胞病毒、甲型或B型流感病毒或人变中性病毒的2岁以下毛细支气管炎住院幼儿的118份鼻咽拭子样本。118份样本中有3份（2.5%）经逆转录-聚合酶链反应检测呈HCoV-NL 63阳性。HCoV-NL 63可能是小儿毛细支气管炎的病原体之一。(C)2005 Wiley-Liss，Inc.
HCoV-NL63, the fourth human coronavirus, has been isolated recently from children with respiratory tract infections, including upper respiratory infection, bronchiolitis, and pneumonia. The virus has been also detected in immunocompromised adults with respiratory tract infections. A total of 118 nasopharyngeal swab samples from 118 hospitalized young children aged less than 2 years with bronchiolitis who were not infected with human respiratory syncytial virus, influenza A or B, or human metaneumovirus were selected. Three (2.5%) of the 118 samples were positive for HCoV-NL63 by reverse transcription-polymerase chain reaction tests. HCoV-NL63 may be one of the causative agents of bronchiolitis in young children. (C) 2005 Wiley-Liss, Inc.