Developmental toxicity study of chlorpyrifos in rats
Developmental toxicity study of chlorpyrifos in rats
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DOI：
10.1016/s0890-6238(02)00121-1
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发表时间：
2003-03-01
影响因子：
3.3
通讯作者：
El-Aswed, AF
中科院分区：
文献类型：
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作者：
Farag, AT;El Okazy, AM;El-Aswed, AF
毒死蜱（O，O-二乙基-O-（3，5，6-三氯-2-吡啶基）-硫代磷酸酯）的潜在发育毒性进行了评价。在妊娠第6-15天，对每组30只繁殖雌性Fischer 344大鼠进行0、5、15和25 mg/kg/天灌胃给药;在妊娠第21天评价胎仔。在每天接受15和25 mg/kg剂量的母鼠中观察到毒死蜱引起的毒性临床体征。这些组的母体效应还包括体重和乙酰胆碱酯酶活性降低。母体剂量为25 mg/kg/天时，胎仔体重和存活率降低，胎仔死亡和早期吸收增加。该组的内脏、骨骼和外部变异也增加。毒死蜱在母体剂量为25毫克/公斤/天时显示出胎儿毒性和致畸作用，这一剂量也产生母体毒性。(C)2002年爱思唯尔科技有限公司All rights reserved.
Chlorpyrifos (O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl)-phosphorothioate) was evaluated for potential developmental toxicity. Groups of 30 bred female Fischer 344 rats were given 0, 5, 15, and 25 mg/kg per day by gavage on gestation days 6-15; the fetuses were evaluated on gestation day 21. Clinical signs of toxicity attributed to chlorpyrifos were, noted in dams receiving 15 and 25 mg/kg per day. Maternal effects in these groups also included depressed body weight and acetylcholinesterase activity. Fetal weight and viability were decreased, and fetal death and early resorption were increased at the 25 mg/kg per day maternal dose. Visceral, skeletal, and external variations were also increased in this group. Chlorpyrifos showed fetotoxic and teratogenic effects at a maternal dose of 25 mg/kg per day, a dose, that also produced maternal toxicity. (C) 2002 Elsevier Science Inc. All rights reserved.