A mathematical model to describe the change in the constitutive character of blood due to platelet activation
A mathematical model to describe the change in the constitutive character of blood due to platelet activation
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DOI：
10.1016/s1631-0721(02)01501-2
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发表时间：
2002-08-01
影响因子：
0.8
通讯作者：
Rajagopal, KR
中科院分区：
文献类型：
--
作者：
Anand, M;Rajagopal, KR
虽然血小板的体积很小，但它可以对血液的流动特性产生深远的影响，从而对心血管功能产生严重的后果。血小板对化学试剂和机械输入极其敏感，血小板活化是许多危及生命的疾病的必要先兆，例如急性心肌梗塞、大多数中风、急性动脉闭塞、静脉血栓形成和肺栓塞。在心室辅助装置和人工心脏瓣膜等心血管装置中，高剪切应力可以触发血小板活化。此外，此类装置具有会形成血栓的人造表面，血栓沉积导致装置失效。因此，需要开发一种考虑血小板活化的血流数学模型，但目前还没有这样的模型。尽管在血液流变学方面已经做了相当多的工作，但血小板在血液流动特性中的作用在很大程度上被忽视了。这项研究弥补了这一缺陷。
Though a minor component by volume, platelets can have a profound influence on the flow characteristics of blood and thereby have serious consequences with regard to cardiovascular functions. Platelets are extremely sensitive to chemical agents as well as mechanical inputs and platelet activation is a necessary precursor to many life threatening medical conditions such as acute myocardial infarction, most strokes, acute arterial occlusion, venous thrombosis and pulmonary embolism. In cardiovascular devices such as ventricular assist devices and prosthetic heart valves, high shear stresses can trigger platelet activation. Moreover, such devices have artificial surfaces that are thrombogenic, the thrombotic deposition contributing to the failure of the device. Thus, there is a need,,to develop a mathematical model for the flow of blood that takes into account platelet activation, no such model being available at the moment. While there has been considerable amount of work in blood rheology, the role of platelets in the flow characteristics of blood has been largely ignored. This study addresses this lacuna.