Synthesis and Conformational Analysis of the First 3-Oxa-7-thia-1-r-azabicyclo[3.3.0]-c-5-octane Single Functionalised at the C-5 Position
Synthesis and Conformational Analysis of the First 3-Oxa-7-thia-1-r-azabicyclo[3.3.0]-c-5-octane Single Functionalised at the C-5 Position
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DOI：
10.2174/157017810791130658
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发表时间：
2010-06-01
影响因子：
0.8
通讯作者：
Darabantu, Mircea
中科院分区：
文献类型：
--
作者：
But, Andrada;Lameiras, Pedro;Darabantu, Mircea
从TRIS[2-氨基-2-（羟甲基）丙烷-1,3-二醇]开始，通过它的类似物2-氨基-2-（巯基）丙烷-1,3-二醇'与甲醛的双环缩合，我们报道了标题系列化合物中第一项的四步合成，在C-5位置具有可开发的羟甲基功能。基于DFT计算和H-1-DNMR讨论了构象分析。
Starting from TRIS [2-amino-2-(hydroxymethyl) propane-1,3-diol] via its thia analogue, 2-amino-2-(mercaptomethyl) propane-1,3-diol' double cyclocondensation with formaldehyde, we report a four steps synthesis of the first term in the title series of compounds, bearing the exploitable hydroxymethyl functionality at the C-5 position. Conformational analysis is discussed based on DFT calculations and H-1-DNMR.