Changes in monocyte functions of astronauts
Changes in monocyte functions of astronauts
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DOI：
10.1016/j.bbi.2004.12.006
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发表时间：
2005-11-01
影响因子：
15.1
通讯作者：
Pierson, DL
中科院分区：
文献类型：
--
作者：
Kaur, I;Simons, ER;Pierson, DL
作为对长时间飞行中先天免疫系统的系统评估的一部分，本研究重点研究了参与航天飞行的宇航员单核细胞的抗菌功能。这项研究包括四次航天飞机任务和25名宇航员。九名非宇航员作为对照。分别在发射前10天、着陆后3小时内和着陆后3天采集血样。在宇航员和对照组中，单核细胞的数量在采样间隔内没有显著差异。然而，在5-11天的太空飞行后，宇航员的单核细胞吞噬大肠杆菌、引发氧化爆发和脱颗粒的能力下降。与对照组相比，航天飞行后的吞噬指数显著降低。吞噬功能的减少伴随着与吞噬作用有关的两个表面标志物CD32和CD64的表达变化。在航天飞行后，皮质醇、肾上腺素和去甲肾上腺素的水平没有比飞行前增加。(C)2005年，爱思唯尔公司出版。
As part of the systematic evaluation of the innate immune system for long duration missions, this study focused on the antimicrobial functions of monocytes in astronauts participating in spaceflight. The study included four space shuttle missions and 25 astronauts. Nine non-astronauts served as controls. Blood specimens were collected 10 days before launch, within 3 h after landing, and again 3 days after landing. The number of monocytes did not differ significantly over the interval sampled in both the astronaut or control groups. However, following 5-11 days of spaceflight, the astronauts' monocytes exhibited reductions in ability to engulf Escherichia coli, elicit an oxidative burst, and degranulate. The phagocytic index was significantly reduced following spaceflight when compared to control values. This reduction in phagocytosis was accompanied by changes in the expression of two surface markers involved in phagocytosis, CD32 and CD64. Levels of cortisol, epinephrine, and norepinephrine after spaceflight did not increase over preflight values. (c) 2005 Published by Elsevier Inc.