The Impact of Nitric Oxide in Cardiovascular Medicine: Untapped Potential Utility
The Impact of Nitric Oxide in Cardiovascular Medicine: Untapped Potential Utility
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DOI：
10.1016/j.amjmed.2009.03.003
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发表时间：
2009-05-01
影响因子：
5.9
通讯作者：
Pepine, Carl J.
中科院分区：
文献类型：
--
作者：
Pepine, Carl J.
内皮的结构完整性和功能活性在动脉粥样硬化和相关不良后果中起着重要作用。心血管疾病危险状况会导致氧化应激，导致一氧化氮（NO）和活性氧之间的平衡被破坏，从而导致血管中生物可利用NO和/或NO可溶性鸟苷酸环化酶级联的相对减少。这导致内皮和血管平滑肌细胞功能障碍，导致细胞生长和基因表达的张力增加和改变，从而产生血栓前、促炎环境。这导致动脉粥样硬化斑块的形成、进展和不稳定，可能导致心肌梗死、中风和心血管死亡。一氧化氮显然在维持和修复血管系统中起着关键作用，生物可利用一氧化氮的减少与不良后果有关。这一背景为探索no -捐献剂在预防心血管不良结局中的潜在治疗作用提供了理论依据。(c) 2009爱思唯尔公司版权所有。美国医学杂志（2009）122,S10-S15
The structural integrity and functional activity of the endothelium play an important role in atherogenesis and related adverse outcomes. Cardiovascular disease risk conditions contribute to oxidative stress, which causes a disruption in the balance between nitric oxide (NO) and reactive oxygen species, with a resulting relative decrease in bioavailable NO and/or the NO-soluble guanylate cyclase cascade in blood vessels. This leads to endothelial and vascular smooth muscle cell dysfunction, resulting in increased tone and alterations in cell growth and gene expression that create a prothrombotic, proinflammatory environment. This leads to formation, progression, and destabilization of atherosclerotic plaques which may result in myocardial infarction, stroke, and cardiovascular death. NO clearly has a critical role in the maintenance and repair of the vasculature, and a decrease in bioavailable NO is linked to adverse outcomes. This background provides the rationale for exploring the potential therapeutic role for NO-donating agents in the prevention of adverse cardiovascular outcomes. (c) 2009 Elsevier Inc. All rights reserved. The American Journal of Medicine (2009) 122, S10-S15