PREFERENTIAL ADHESION OF TECTAL MEMBRANES TO ANTERIOR EMBRYONIC CHICK RETINA NEURITES
PREFERENTIAL ADHESION OF TECTAL MEMBRANES TO ANTERIOR EMBRYONIC CHICK RETINA NEURITES
复制标题
DOI：
10.1038/292067a0
复制
发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
SCHWARZ, U
中科院分区：
文献类型：
--
作者：
HALFTER, W;CLAVIEZ, M;SCHWARZ, U
胚胎发生过程中细胞之间的识别对于形成精确图案的神经元网络至关重要，例如轴突从视网膜投射到鸟类光学系统的顶盖上。检测到视网膜和顶盖细胞之间的粘附梯度，来自神经视网膜背侧区域的细胞优先粘附到视觉顶盖腹侧一半的细胞，反之亦然。细胞之间的拓扑关系可以通过细胞表面的标记来建立。这些发现基于细胞体之间的粘附，而只有视网膜神经节细胞的轴突尖端与顶盖细胞接触并可能识别顶盖细胞。在这里，使用了一种系统，其中视网膜向外生长的神经突在体外暴露于顶盖细胞表面。小鸡的视网膜有明显的前后极性。
Recognition between cells during embryogenesis is essential for the formation of precisely patterned neuronal networks, such as the projection of axons from the retina on to the tectum in the avian optical system. A gradient of adhesion between retinal and tectal cells was detected, with cells from the dorsal area of the neural retina adhering preferentially to cells of the ventral half of the visual tecta and vice versa. Topological relationship between cells may be established through markers on the cell surface. Such findings are based on adhesion between cell bodies, whereas it is only the axon tip of the retina ganglion cell which makes contact with, and presumably recognizes tectal cells. Here, a system in which outgrowing neurites from the retina were exposed to tectal cell surfaces in vitro was used. There was a striking antero-posterior polarity in the chick retina.