Graft copolymers having hydrophobic backbone and hydrophilic branches. XXIII. Particle size control of poly(ethylene glycol)-coated polystyrene nanoparticles prepared by macromonomer method
Graft copolymers having hydrophobic backbone and hydrophilic branches. XXIII. Particle size control of poly(ethylene glycol)-coated polystyrene nanoparticles prepared by macromonomer method
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DOI：
10.1002/(sici)1099-0518(19990701)37:13
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发表时间：
1999-07
期刊：
影响因子：
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通讯作者：
Mingqing Chen;T. Serizawa;A. Kishida;M. Akashi
中科院分区：
文献类型：
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作者：
Mingqing Chen;T. Serizawa;A. Kishida;M. Akashi
以苯乙烯（St）和末端带有甲基丙烯酰基（MMA-PEG）或对乙烯基苄基（St-PEG）的聚乙二醇（PEG）为单体，在不同的有机溶剂/水介质中进行分散共聚，制备了以聚苯乙烯（PS）为核，表面带有聚乙二醇（PEG）支链的单分散聚合物纳米球。纳米球表面的电子能谱化学分析（ESCA）表明，PEG大分子单体链有利地位于其表面上。通过扫描电子显微镜（SEM）观察纳米球的形态，并通过亚微米颗粒分析仪估计颗粒尺寸。当大分子单体的浓度和分子量都较高时，可得到直径较小的纳米球。使用低分子量的大分子单体在较低浓度下获得直径较大的纳米球。与不同浓度单位的直径（Dn）相关的函数为Dn = K[St]0.64[MMA-PEG]-0.53 ±0.01[I]-0.49和Dn = K[St]0.80[St-PEG]-0.69 ±0.01[I]-0.22，其中[I]、[St]、[MMA-PEG]和[St-PEG]分别是进料中引发剂、苯乙烯、MMA-PEG和St-PEG大分子单体的浓度。当反应参数如大分子单体的分子量选择适当时，可将粒径控制在约100 ~ 1000 μ m之间。80至3100 nm。© 1999 John Wiley & Sons，Inc.聚合物科学杂志A：聚合物化学37：2155-2166，1999
Monodisperse polymeric nanospheres, which consist of polystyrene cores and poly(ethylene glycol) (PEG) branches on their surfaces, were prepared by the dispersion copolymerization of styrene (St) with PEG macromonomers that had a methacryloyl (MMA-PEG) or p-vinylbenzyl (St-PEG) end group in various organic solvent/water media. Electron spectroscopy for chemical analysis (ESCA) of the nanosphere surfaces indicated that PEG macromonomer chains were favorably located on their surfaces. The morphologies of the nanospheres were observed via a scanning electron micrograph (SEM), and particle sizes were estimated by a submicron particle analyzer. When both the concentration of macromonomers and molecular weight were higher, small nanospheres in diameter were obtained. Larger nanospheres in diameter were obtained using macromonomers with low molecular weight at lower concentration. The functions that correlate the diameter (Dn) on different concentration units were Dn = K[St]0.64[MMA-PEG]−0.53±0.01[I]−0.49 and Dn = K[St]0.80[St-PEG]−0.69±0.01[I]−0.22, where [I], [St], [MMA-PEG], and [St-PEG] are initiator, styrene, MMA-PEG, and St-PEG macromonomer concentration in feed, respectively. When the reaction parameters such as the molecular weight of the macromonomers were properly chosen, the particle size could be controlled in a range from ca. 80 to 3100 nm. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 2155–2166, 1999