Improved disorder prediction by combination of orthogonal approaches.

Improved disorder prediction by combination of orthogonal approaches.
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DOI:
10.1371/journal.pone.0004433
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发表时间:
2009
期刊:
影响因子:
3.7
通讯作者:
Rost B
Rost B
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Schlessinger A;Punta M;Yachdav G;Kajan L;Rost B

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无序蛋白在转录和细胞信号等调控过程中含量非常丰富。已经开发了不同的方法来预测蛋白质紊乱,通常侧重于不同类型的紊乱区域。在这里,我们提出了MD,一种新的Meta-Disorder预测方法,它对主要从正交预测方法获得的各种信息源进行建模,以显著提高其成分的性能。在持续的交叉验证中,MD不仅表现优于它的起源,而且在我们应用的各种测试中,它也比其他最先进的预测方法更有利。可用性:http://www.rostlab.org/services/md/
Disordered proteins are highly abundant in regulatory processes such as transcription and cell-signaling. Different methods have been developed to predict protein disorder often focusing on different types of disordered regions. Here, we present MD, a novel META-Disorder prediction method that molds various sources of information predominantly obtained from orthogonal prediction methods, to significantly improve in performance over its constituents. In sustained cross-validation, MD not only outperforms its origins, but it also compares favorably to other state-of-the-art prediction methods in a variety of tests that we applied. Availability: http://www.rostlab.org/services/md/
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