Modulation of endothelial cell damages by anti-Hsp60 autoantibodies in systemic autoimmune diseases
Modulation of endothelial cell damages by anti-Hsp60 autoantibodies in systemic autoimmune diseases
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DOI：
10.1016/j.autrev.2007.01.012
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发表时间：
2007-08-01
影响因子：
13.6
通讯作者：
Jamin, Christophe
中科院分区：
文献类型：
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作者：
Alard, Jean-Eric;Dueymes, Maryvonne;Jamin, Christophe
热休克蛋白(HSP)家族由多种异质蛋白组成，其中研究最多的是HSP60成员。现在普遍认为，HSP60不仅是线粒体的一种成分，而且可以定位于膜细胞表面。Hsp60被认为是感染后的信号危险，它可以诱导产生抗Hsp60抗体，作为防御病原体的机制。然而，在自身免疫性疾病、动脉粥样硬化和血管疾病中，内源性Hsp60也是自身抗体的靶点，在这些疾病中会产生抗内皮细胞抗体(AECA)。热休克蛋白60是一种内皮细胞自身抗原，当被相关自身抗体识别时，能够触发细胞毒反应和细胞凋亡反应。根据Hsp60表位特异性的不同，具有Hsp60反应性的AECA的功能效应可能有所不同。这些观察结果表明，只要准确地表征了特定的Hsp60表位，避免由于抗Hsp60自身抗体而导致的内皮细胞损伤的新的治疗方法将是成功的。(C)2007 Elsevier B.V.保留所有权利。
Heat-shock protein (Hsp) family is made up of heterogeneous proteins of which Hsp60 members are the most studied. It is now generally admitted that Hsp60 is not only a mitochondrial component but can be localized on the membrane cell surface. Considered as a signal danger following infections, Hsp60 can induce the production of anti-Hsp60 antibodies as defense mechanisms against pathogens. However, endogenous Hsp60 is also a target of autoantibodies in autoimmune disorders, atherosclerosis and vascular diseases, in which anti-endothelial cell antibodies (AECA) are generated. Hsp60 is one of the endothelial cell autoantigens able to trigger cytotoxic and apoptotic responses when recognized by the related autoantibodies. Depending on the Hsp60 epitope specificity, it appears that AECA with Hsp60 reactivity may differ in their functional effects. These observations suggest that new therapeutic approach to avoid endothelial cell damages due to anti-Hsp60 autoantibodies would be successful provided that specific Hsp60 epitopes would have been precisely characterized. (c) 2007 Elsevier B.V. All rights reserved.