Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort.
Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort.
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较高的饮食炎症指数分数与大脑衰老的大脑 MRI 标记相关：来自弗雷明汉心脏研究后代队列的结果。
DOI：
10.1002/alz.12685
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Jacob,MiniE
中科院分区：
文献类型：
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作者：
MeloVanLent,Debora;Gokingco,Hannah;Short,MeghanI;Yuan,Changzheng;Jacques,PaulF;Romero,JoséR;DeCarli,CharlesS;Beiser,AlexaS;Seshadri,Sudha;Himali,JayandraJ;Jacob,MiniE
简介我们调查了弗雷明汉心脏研究后代队列参与者的饮食炎症指数 (DII) 与脑容量和脑小血管疾病测量之间的横断面关联。方法共有 1897 名参与者（平均值±标准差，年龄 62±9）完成了食物频率调查问卷和脑磁共振成像 (MRI)。结果在最多三个时间点平均的较高（促炎症）DII 分数与较小的总脑容量（β±标准误差：–0.16 ± 0.03；P< .0001) 调整人口、临床和生活方式协变量后。此外，较高的 DII 评分与较小的总灰质体积 (–0.08 ± 0.03；P= .003) 和较大的侧脑室体积 (0.04 ± 0.02；P= .03) 相关。没有观察到与其他脑部 MRI 测量值之间的关联。讨论我们的研究结果显示较高的 DII 评分与整体脑部 MRI 测量值之间存在关联。由于我们是第一批报告较高 DII 分数与脑容量之间关联的小组之一，因此需要重复来证实我们的发现。
IntroductionWe investigated cross‐sectional associations between the Dietary Inflammatory Index (DII) and measures of brain volume and cerebral small vessel disease among participants of the Framingham Heart Study Offspring cohort.MethodsA total of 1897 participants (mean ± standard deviation, age 62±9) completed Food Frequency Questionnaires and brain magnetic resonance imaging (MRI).ResultsHigher (pro‐inflammatory) DII scores, averaged across a maximum of three time points, were associated with smaller total brain volume (beta ± standard error: –0.16 ± 0.03;P< .0001) after adjustment for demographic, clinical, and lifestyle covariates. In addition, higher DII scores were associated with smaller total gray matter volume (–0.08 ± 0.03;P= .003) and larger lateral ventricular volume (0.04 ± 0.02;P= .03). No associations were observed with other brain MRI measures.DiscussionOur findings showed associations between higher DII scores and global brain MRI measures. As we are one of the first groups to report on the associations between higher DII scores and brain volume, replication is needed to confirm our findings.