Catecholamine uptake, melanization, and oxygen toxicity in Cryptococcus neoformans
Catecholamine uptake, melanization, and oxygen toxicity in Cryptococcus neoformans
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新型隐球菌的儿茶酚胺摄取、黑化和氧毒性
DOI：
10.1128/jb.173.1.401-403.1991
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发表时间：
1991
影响因子：
3.2
通讯作者：
H. S. Emery
中科院分区：
文献类型：
--
作者：
E. Jacobson;H. S. Emery
新生隐球菌的氧敏突变定位于3个遗传位点。三个氧敏感突变体的突变似乎是等位基因，并表现出与氧敏感密切相关的白化；这三个和第四个突变株在儿茶酚摄取和儿茶酚氧化为黑色素方面存在缺陷。儿茶酚胺代谢似乎可以保护新生葡萄球菌免受氧化剂的侵害。
Oxygen sensitivity mutations of Cryptococcus neoformans were mapped to three genetic loci. Three oxygen-sensitive mutants had mutations that appeared allelic and exhibited albinism tightly linked to oxygen sensitivity; these three and a fourth exhibited defects in catechol uptake and catechol oxidation to melanin. Catecholamine metabolism appears to protect C. neoformans from oxidants.