Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease.
Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease.
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对具有常染色体显性遗传或迟发性阿尔茨海默病父母史的无症状中年个体的生物标志物和认知进行横断面和纵向比较。
DOI：
10.1002/alz.12912
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Cruchag
中科院分区：
文献类型：
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作者：
Xiong,Chengjie;McCue,LenaM;Buckles,Virginia;Grant,Elizabeth;Agboola,Folasade;Coble,Dean;Bateman,RandallJ;Fagan,AnneM;Benzinger,TammieLS;Hassenstab,Jason;Schindler,SuzanneE;McDade,Eric;Moulder,Krista;Gordon,BrianA;Cruchag
BackgroundComparisons of late‐onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age.MethodsWe compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and amyloid imaging with Pittsburgh Compound‐B (PiB) across four groups of 387 cognitively normal participants, 42 to 65 years of age, in the Dominantly Inherited Alzheimer Network (DIAN) and the Adult Children Study (ACS) of LOAD: DIAN mutation carriers (MCs) and non‐carriers (NON‐MCs), and ACS participants with a positive (FH+) and negative (FH–) family history of LOAD.ResultsAt baseline, MCs had the lowest age‐adjusted level of CSF Aβ42 and the highest levels of total and phosphorylated tau‐181, and PiB uptake. Longitudinally, MC had similar increase in PiB uptake to FH+, but drastically faster decline in hippocampal volume than others, and was the only group showing cognitive decline.DiscussionPreclinical ADAD and LOAD share many biomarker signatures, but cross‐sectional and longitudinal differences may exist.
