Melatonin and Hypothalamic-Pituitary-Gonadal Axis
Melatonin and Hypothalamic-Pituitary-Gonadal Axis
复制标题
褪黑激素和下丘脑-垂体-性腺轴。
DOI：
10.2174/09298673113209990114
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发表时间：
2013-05-01
影响因子：
4.1
通讯作者：
Xu, Z.
中科院分区：
文献类型：
--
作者：
Shi, L.;Li, N.;Xu, Z.
褪黑激素（N-乙酰基-5-甲氧基色胺）是松果体的主要产物，主要在昼夜节律周期的黑暗阶段产生。这种激素在生理和神经内分泌功能的各个方面的昼夜节律和季节变化的调节中起着至关重要的作用。在哺乳动物中，褪黑激素可以通过激活其下丘脑-垂体-性腺（HPG）轴上的受体和结合位点来影响性成熟和生殖功能。本文综述了褪黑激素对下丘脑、垂体和性腺的作用。本文还综述了褪黑激素在临床应用的最新进展，以及褪黑激素作为氧化应激的降低剂在改善生殖功能方面的应用前景。
Melatonin (N-acetyl-5-methoxy-tryptamine), a principal product of the pineal gland, is produced mainly during the dark phase of the circadian cycle. This hormone plays a crucial role in the regulation of circadian and seasonal changes in various aspects of physiology and neuroendocrine functions. In mammals, melatonin can influence sexual maturation and reproductive functions via activation of its receptors and binding sites in the hypothalamic-pituitary-gonadal (HPG) axis. This review summarizes current knowledge of melatonin on the hypothalamus, pituitary gland, and gonads. We also review recent progress in clinical applications of melatonin or potentials of using melatonin, as a reducer of oxidative stress, to improve reproductive functions for the diseases such as women infertility.