Cerebrospinal Fluid Neuropeptide Y-like Immunoreactivity Correlates with Impulsive Aggression in Human Subjects
Cerebrospinal Fluid Neuropeptide Y-like Immunoreactivity Correlates with Impulsive Aggression in Human Subjects
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DOI：
10.1016/j.biopsych.2012.07.029
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发表时间：
2012-12-15
影响因子：
10.6
通讯作者：
Mathe, Aleksander A.
中科院分区：
文献类型：
--
作者：
Coccaro, Emil F.;Lee, Royce;Mathe, Aleksander A.
背景：神经化学研究已经指出了许多中枢神经递质在人类攻击性中的调节作用;一些（例如，5-羟色胺）似乎起抑制作用，而其它（例如，加压素）似乎在攻击性的调节中起促进作用。虽然最近的动物神经肽Y（NPY）的研究表明，一个调解人的作用，中央神经肽Y的调制侵略，还没有人类的研究报告关于aggression.Methods：基础腰椎脑脊液（CSF）获得60个身体健康的受试者与人格障碍（PD）（n = 40）和健康志愿者（n = 20）。然后，这些样本进行了评估CSF神经肽Y样免疫反应性（NPY-LI）和其他神经递质相关的物种在CSF和相关的侵略和impulsivity.Results的措施：脑脊液NPY-LI是较高的PD受试者与健康志愿者相比，间歇性爆炸性障碍的受试者与那些没有间歇性爆炸性障碍。在PD受试者中，CSF NPY-LI与攻击性和冲动性的复合测量值以及冲动攻击性的复合测量值直接相关。CSF-NPY-LI浓度的组间差异占冲动aggression.Conclusions的措施：这些数据表明CSF NPY免疫反应性浓度和人类受试者的冲动侵略措施之间的直接关系。这增加了人类受试者中冲动性攻击的中枢神经调节作用的复杂画面。
Background: Neurochemical studies have pointed to a modulatory role in human aggression for a number of central neurotransmitters; some (e.g., serotonin) appear to play an inhibitory role, while others (e.g., vasopressin) appear to play a facilitator role in the modulation of aggression. While recent animal studies of neuropeptide Y (NPY) have suggested a facilitator role for central NPY in the modulation of aggression, no human studies of central NPY have yet been reported regarding aggression.Methods: Basal lumbar cerebrospinal fluid (CSF) was obtained from 60 physically healthy subjects with personality disorder (PD) (n = 40) and from healthy volunteers (n = 20). These samples were then assessed for CSF NPY-like immuno reactivity (NPY-LI) and other neuro transmitter-related species in CSF and correlated with measures of aggression and impulsivity.Results: Cerebrospinal fluid NPY-LI was higher in PD subjects compared with healthy volunteers and in subjects with intermittent explosive disorder compared with those without intermittent explosive disorder. In PD subjects, CSF NPY-LI was directly correlated with composite measures of aggression and impulsivity and a composite measure of impulsive aggression. Group differences in CSF-NPY-LI concentration were accounted for by measures of impulsive aggression.Conclusions: These data suggest a direct relationship between CSF NPY-immunoreactivity concentration and measures of impulsive aggression in human subjects. This adds to the complex picture of the central neuromodulatory role of impulsive aggression in human subjects.