Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study
Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study
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DOI：
10.1016/s0140-6736(06)67922-1
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发表时间：
2006-01-07
期刊：
影响因子：
168.9
通讯作者：
Cooper, C
中科院分区：
文献类型：
--
作者：
Javaid, MK;Crozier, SR;Cooper, C
背景 维生素 D 不足在育龄妇女中很常见，越来越多的证据表明，成年期骨质疏松性骨折的风险可能部分取决于子宫内和产后早期的环境因素。我们调查了怀孕期间母亲维生素 D 状态对儿童骨骼生长的影响。方法 在一项纵向研究中，我们研究了 1991-92 年出生于英国南安普敦一家医院的 198 名儿童；她们母亲在怀孕期间的体型、营养和维生素 D 状况都得到了表征。孩子们在 9 岁时进行了随访，以将这些母亲特征与其体型和骨量联系起来。结果显示，在怀孕后期，49 名 (31%) 名母亲体内 25(OH)-维生素 D 的循环浓度不足，28 名 (18%) 名母亲体内 25(OH)-维生素 D 的循环浓度不足。妊娠晚期母亲体内 25(OH)-维生素 D 浓度降低与 9 岁时儿童全身 (r=0.21，p=0.0088) 和腰椎 (r=0.17，p=0.03) 骨矿物质含量降低相关。妊娠晚期暴露于紫外线 B 辐射的估计值和母亲使用维生素 D 补充剂的情况都可以预测母亲 25(OH)-维生素 D 浓度 (p
Background Vitamin D insufficiency is common in women of childbearing age and increasing evidence suggests that the risk of osteoporotic fracture in adulthood could be determined partly by environmental factors during intrauterine and early postnatal life. We investigated the effect of maternal vitamin D status during pregnancy on childhood skeletal growth.Methods In a longitudinal study, we studied 198 children born in 1991-92 in a hospital in Southampton, UK; the body build, nutrition, and vitamin D status of their mothers had been characterised during pregnancy. The children were followed up at age 9 years to relate these maternal characteristics to their body size and bone mass.Findings 49 (31%) mothers had insufficient and 28 (18%) had deficient circulating concentrations of 25(OH)-vitamin D during late pregnancy. Reduced concentration of 25(OH)-vitamin D in mothers during late pregnancy was associated with reduced whole-body (r=0.21, p=0.0088) and lumbar-spine (r=0.17, p=0.03) bone-mineral content in children at age 9 years. Both the estimated exposure to ultraviolet B radiation during late pregnancy and the maternal use of vitamin D supplements predicted maternal 25(OH)-vitamin D concentration (p