Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1.
Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1.
复制标题
芹菜素通过抑制葡萄糖转运蛋白 1 抑制腺样囊性癌的增殖
DOI：
10.3892/mmr.2015.4233
复制
发表时间：
2015-11
影响因子：
3.4
通讯作者：
Fan J
中科院分区：
文献类型：
--
作者：
Fang J;Bao YY;Zhou SH;Fan J
芹菜素是一种天然植物雌激素类黄酮，具有抗氧化、抗炎、抗癌等多种生物学活性。此外，最近有报道将芹菜素作为低氧标记物的靶点；然而，目前还没有关于芹菜素与葡萄糖转运蛋白-1(GLUT-1)在腺样囊性癌(ACC)中的相关性的研究。本研究探讨了芹菜素是抑制ACC细胞的增殖，还是抑制ACC细胞中GLUT-1的表达。本研究结果表明，芹菜素以剂量和时间依赖的方式抑制ACC-2细胞的生长。芹菜素还以剂量和时间依赖的方式诱导细胞凋亡和G2/M期停滞。与上述结果相对应，GLUT-1的表达水平在治疗后显著降低，且呈剂量和时间依赖关系。以上结果提示，芹菜素抑制ACC-2细胞生长可能与其下调GLUT-1的表达有关。
Apigenin is a natural phyto-oestrogen flavonoid, which exerts various biological effects, including anti-oxidative, anti-inflammatory and anticancer activities. In addition, apigenin has recently been reported to target hypoxic markers; however, there are currently no studies regarding the association between apigenin and glucose transporter-1 (GLUT-1) in adenoid cystic carcinoma (ACC). The present study investigated whether apigenin inhibits the proliferation of ACC cells or suppresses the expression of GLUT-1 in ACC cells. The results of the present study demonstrated that apigenin inhibits ACC-2 cell growth in a dose- and time-dependent manner. Treatment with apigenin also induced apoptosis and G2/M-phase arrest in a dose- and time-dependent manner. Corresponding with the above results, the expression levels of GLUT-1 were significantly decreased following treatment in a dose- and time-dependent manner. These results suggest that the inhibition of ACC-2 cell growth by apigenin may be due to the decreased expression of GLUT-1.