An anthropomorphic phantom for quantitative evaluation of breast MRI
An anthropomorphic phantom for quantitative evaluation of breast MRI
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DOI：
10.1118/1.3533899
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发表时间：
2011-02-01
期刊：
影响因子：
3.8
通讯作者：
Badano, Aldo
中科院分区：
文献类型：
--
作者：
Freed, Melanie;de Zwart, Jacco A.;Badano, Aldo
目的：在本研究中，作者旨在开发一种物理的、组织模拟的假体，用于定量评估乳腺MRI方案。该模型的目的是为了解决乳房MRI中改进标准化的需要，并为评估图像协议参数对病变检测和识别的影响提供一个平台。给出了患者和幻影图像特性的定量比较。方法：使用猪油和蛋清的混合物构建假体，产生具有独立的脂肪和腺体模拟成分的随机结构。利用最大似然方法，从反演恢复和自旋回波扫描中分别估计幻体的猪油和鸡蛋成分的T(1)和T(2)弛豫时间为1.5 T。通过计算和比较幻影图像和患者图像的空间协方差矩阵，定量地检验图像结构。通过用立体光刻技术创建一个空心模具并填充掺杂钆的水溶液，引入了一个静态增强病变。结果：测量到的幻肢松弛值与文献中人类值相差2个标准误差以内，并且在9个月的测试中相当稳定。将幻像与患者数据的协方差矩阵进行比较，发现幻像与患者数据具有相似的图像结构。它们的协方差矩阵在前后方向误差条内相同，在左右方向误差条内相同。来自幻肢脂肪模拟材料的信号可以通过主动脂肪抑制协议来抑制。静态增强病变也可以包括改变形态和造影剂浓度的能力。结论：作者已经构建了一个假体，并证明了它在与乳房MRI相关的关键物理特性方面模仿人类乳房图像的能力。该模型为乳腺MRI成像方案的优化和标准化提供了一个平台，用于病变检测和表征。(DOI: 10.1118/1.3533899)
Purpose: In this study, the authors aim to develop a physical, tissue-mimicking phantom for quantitative evaluation of breast MRI protocols. The objective of this phantom is to address the need for improved standardization in breast MRI and provide a platform for evaluating the influence of image protocol parameters on lesion detection and discrimination. Quantitative comparisons between patient and phantom image properties are presented.Methods: The phantom is constructed using a mixture of lard and egg whites, resulting in a random structure with separate adipose- and glandular-mimicking components. T(1) and T(2) relaxation times of the lard and egg components of the phantom were estimated at 1.5 T from inversion recovery and spin-echo scans, respectively, using maximum-likelihood methods. The image structure was examined quantitatively by calculating and comparing spatial covariance matrices of phantom and patient images. A static, enhancing lesion was introduced by creating a hollow mold with stereolithography and filling it with a gadolinium-doped water solution.Results: Measured phantom relaxation values fall within 2 standard errors of human values from the literature and are reasonably stable over 9 months of testing. Comparison of the covariance matrices of phantom and patient data demonstrates that the phantom and patient data have similar image structure. Their covariance matrices are the same to within error bars in the anterior-posterior direction and to within about two error bars in the right-left direction. The signal from the phantom's adipose-mimicking material can be suppressed using active fat-suppression protocols. A static, enhancing lesion can also be included with the ability to change morphology and contrast agent concentration.Conclusions: The authors have constructed a phantom and demonstrated its ability to mimic human breast images in terms of key physical properties that are relevant to breast MRI. This phantom provides a platform for the optimization and standardization of breast MRI imaging protocols for lesion detection and characterization. [DOI: 10.1118/1.3533899]