PLASMA FREE FATTY ACID IN LIVER DISEASE
PLASMA FREE FATTY ACID IN LIVER DISEASE
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DOI：
10.1136/gut.2.4.304
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发表时间：
1961-01-01
期刊：
影响因子：
24.5
通讯作者：
DAWSON, AM
中科院分区：
文献类型：
--
作者：
MORTIAUX, A;DAWSON, AM
131例各种肝病患者的血浆游离脂肪酸水平多数升高，包括肝细胞损害严重的患者和肝细胞功能相对较好的患者和梗阻性黄疸患者。这一水平的升高可能是由于储藏脂肪的增加，因为葡萄糖抑制了游离脂肪酸的外周释放，导致血浆水平下降，并消除了与正常人相当的肝病患者的股静脉-动脉差异。此外，用棕榈酸酯-1-C14测定血浆游离脂肪酸流量，发现肝病患者血浆游离脂肪酸流量增加。
The plasma free fatty acid level was raised in the majority of 131 patients with a variety of liver disorders, and included both those with severe liver cell damage and those with relatively good liver cell function and obstructive jaundice. This raised level is probably due to an increased mobilization of depot fat, for glucose, which inhibits peripheral liberation of free fatty acids, caused a fall in the plasma level and obliteration of the femoral venous-arterial difference in patients with liver disease comparable with that in normal persons. In addition, the plasma free fatty acid flux was measured using palmitate-1-C14 and was found to be increased in patients with liver disease.