Persistent representation of the environment in the hippocampus
Persistent representation of the environment in the hippocampus
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DOI：
10.1016/j.celrep.2022.111989
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发表时间：
2023-01-11
期刊：
影响因子：
8.8
通讯作者：
Matsuo, Naoki
中科院分区：
文献类型：
--
作者：
Kobayashi, Kyogo S.;Matsuo, Naoki
在海马体中，环境变化会引起活跃神经元群的重新排列或位置细胞的重新映射。然而，尽管那里发生了显著的事件，但大脑如何确保对特定环境本身的一致表征仍然令人费解。在这里，我们纵向跟踪了接受背景恐惧条件反射和消退训练的小鼠背侧海马CA1区神经元的钙动力学。总体而言，人口活动因恐惧条件反射而显着改变，并对脚部电击和冰冻做出反应。然而，一小部分神经元，被称为环境细胞，在特定的环境中始终活跃，无论经历如何。一项解码子模型研究表明，这些细胞，而不是定位细胞，能够预测小鼠所处的环境。环境细胞可能是跨越时间和事件对不同环境的恒定认知的基础。此外，我们的研究强调了海马区细胞的功能异质性。
In the hippocampus, environmental changes elicit rearrangement of active neuronal ensembles or remapping of place cells. However, it remains elusive how the brain ensures a consistent representation of a certain environment itself despite salient events occurring there. Here, we longitudinally tracked calcium dynamics of dorsal hippocampal CA1 neurons in mice subjected to contextual fear conditioning and extinction training. Overall population activities were significantly changed by fear conditioning and were responsive to footshocks and freezing. However, a small subset of neurons, termed environment cells, were consistently active in a specific environment irrespective of experiences. A decoder modeling study showed that these cells, but not place cells, were able to predict the environment to which the mouse was exposed. Environment cells might underlie the constancy of cognition for distinct environments across time and events. Addition-ally, our study highlights the functional heterogeneity of cells in the hippocampus.