Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis.
Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis.
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DOI：
10.1016/j.neubiorev.2018.04.003
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发表时间：
2018-07
影响因子：
8.2
通讯作者：
Stehouwer CDA
中科院分区：
文献类型：
--
作者：
Rensma SP;van Sloten TT;Launer LJ;Stehouwer CDA
脑小血管病（CSVD）的MRI特征，即白色高信号、腔隙、微出血、血管周围间隙和脑萎缩，可能与临床事件相关，但这些相关性的强度尚不清楚。我们对这些特征与缺血性和出血性卒中、全因痴呆和抑郁以及全因死亡率之间的关联进行了系统回顾和荟萃分析。对于与中风的相关性，确定了36项研究（个体/事件[n] = 38，432/4，136），痴呆28项（n = 16，458/1，709），抑郁症9项（n = 9，538/1，746）和死亡率28项（n = 23，031/2，558）。仅2项研究评价了血管周围间隙;未汇总这些结果。汇总分析显示，所有其他特征与所有结局相关（风险比范围为1.22-2.72）。两个特征的组合与中风的相关性比任何单独的特征更强。个体特征和CSVD特征的组合与缺血性和出血性卒中、全因痴呆和抑郁以及全因死亡率密切相关。如果这些关联是因果关系，这些关联的强度表明，大量的疾病负担可归因于CSVD。
MRI features of cerebral small vessel disease (CSVD), i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. We conducted a systematic review and meta-analysis on the association between these features and incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. For the association with stroke, 36 studies were identified (number of individuals/events [n] = 38,432/4,136), for dementia 28 (n = 16,458/1,709), for depression nine (n = 9,538/1,746), and for mortality 28 (n = 23,031/2,558). Only two studies evaluated perivascular spaces; these results were not pooled. Pooled analyses showed that all other features were associated with all outcomes (hazard ratios ranged 1.22–2.72). Combinations of two features were more strongly associated with stroke than any individual feature. Individual features and combinations of CSVD features are strongly associated with incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. If these associations are causal, the strength of these associations suggests that a substantial burden of disease is attributable to CSVD.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
DOI：
10.1177/0271678x15606723
发表时间：
2016-02
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Østergaard L;Engedal TS;Moreton F;Hansen MB;Wardlaw JM;Dalkara T;Markus HS;Muir KW
通讯作者：
Muir KW
影响因子：
2.7
作者：
Barengo, N. C.;Antikainen, R.;Tuomilehto, J.
通讯作者：
Tuomilehto, J.
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
4.8
作者：
Huijts M;Duits A;van Oostenbrugge RJ;Kroon AA;de Leeuw PW;Staals J
通讯作者：
Staals J