Transfer of antibiotics and their metabolites in human milk: Implications for infant health and microbiota.
Transfer of antibiotics and their metabolites in human milk: Implications for infant health and microbiota.
复制标题
抗生素及其代谢物在母乳中的转移：对婴儿健康和微生物群的影响。
DOI：
10.1002/phar.2732
复制
发表时间：
2023
期刊：
影响因子：
4.1
通讯作者：
Tremoulet,AdrianaH
中科院分区：
文献类型：
--
作者：
Thomas,SydneyP;Denizer,Erce;Zuffa,Simone;Best,BrookieM;Bode,Lars;Chambers,ChristinaD;Dorrestein,PieterC;Liu,GeorgeY;Momper,JeremiahD;Nizet,Victor;Tsunoda,ShirleyM;Tremoulet,AdrianaH
抗生素是围产期护理的重要工具。虽然抗生素可以对父母和婴儿起到挽救生命的作用，但它们也会对构成宿主肠道微生物区系的有益细菌造成附带损害。对于婴儿来说尤其如此，他们发育中的肠道微生物群对抗生素的扰动特别敏感。新出现的证据表明，在这个关键的发育窗口扰乱这些细菌种群可能会对婴儿的健康和发育产生长期影响。尽管目前的大多数研究都集中在婴儿直接服用抗生素或产前接触母亲服用的抗生素造成的微生物干扰，但关于母乳中的抗生素是否会对婴儿构成类似的风险，人们知之甚少。这篇综述综述了目前有关哺乳期抗生素转移的数据，并强调了评估母乳药物转移的新方法。最后，我们对未来的工作提出了建议，以确保哺乳期父母使用抗生素对父母和婴儿都是安全和有效的。
Antibiotics are an essential tool for perinatal care. While antibiotics can play a life‐saving role for both parents and infants, they also cause collateral damage to the beneficial bacteria that make up the host gut microbiota. This is especially true for infants, whose developing gut microbiota is uniquely sensitive to antibiotic perturbation. Emerging evidence suggests that disruption of these bacterial populations during this crucial developmental window can have long‐term effects on infant health and development. Although most current studies have focused on microbial disruptions caused by direct antibiotic administration to infants or prenatal exposure to antibiotics administered to the mother, little is known about whether antibiotics in human milk may pose similar risks to the infant. This review surveys current data on antibiotic transfer during lactation and highlights new methodologies to assess drug transfer in human milk. Finally, we provide recommendations for future work to ensure antibiotic use in lactating parents is safe and effective for both parents and infants.