Metrics on RNA secondary structures
Metrics on RNA secondary structures
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DOI：
10.1089/10665270050081522
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发表时间：
2000-02-01
影响因子：
1.7
通讯作者：
Penny, D
中科院分区：
文献类型：
--
作者：
Moulton, V;Zuker, M;Penny, D
人们开发了许多不同的程序来预测RNA序列的二级结构，其中一些程序生成了一个结构集合，所有这些结构的自由能都接近于最佳结构，这使得能够量化这些不同结构的相似程度变得很重要。为了解决这一问题，我们在固定长度的RNA二级结构集合上定义了一类新的度量，即山度量，并将这些度量与其他已知的RNA二级结构度量进行了比较。我们还研究了这些度量的一些全局和局部性质。
Many different programs have been developed for the prediction of the secondary structure of an RNA sequence, Some of these programs generate an ensemble of structures, all of which have free energy close to that of the optimal structure, making it important to be able to quantify how similar these different structures are. To deal with this problem, we define a new class of metrics, the mountain metrics, on the set of RNA secondary structures of a fixed length, We compare properties of these metrics with other well known metrics on RNA secondary structures. We also study some global and local properties of these metrics.