Curcumin treatment provides protection against Trypanosoma cruzi infection.
Curcumin treatment provides protection against Trypanosoma cruzi infection.
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DOI：
10.1007/s00436-011-2790-9
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发表时间：
2012-06
影响因子：
2
通讯作者：
Tanowitz HB
中科院分区：
文献类型：
--
作者：
Nagajyothi F;Zhao D;Weiss LM;Tanowitz HB
克氏锥虫是恰加斯病的病原体，可引起急性心肌炎和慢性心肌病。目前针对这种疾病的治疗药物并不总是有效，并且常常具有严重的副作用。姜黄素是一种植物多酚，已被证明具有广泛的潜在治疗作用。在这项研究中，我们检查了姜黄素对体外和体内克氏锥虫感染的影响。姜黄素预处理成纤维细胞抑制寄生虫入侵。治疗减少了低密度脂蛋白受体的表达，该受体参与克氏锥虫宿主细胞的侵袭。姜黄素治疗克氏锥虫感染的 CD1 小鼠可减少寄生虫血症并减少受感染心脏组织的寄生。这与心脏和肝脏中巨噬细胞浸润和炎症的显着减少有关。此外，经姜黄素治疗的感染小鼠表现出 100% 的存活率，而未经治疗的感染小鼠通常为 60% 的存活率。这些数据与姜黄素调节感染诱导的涉及炎症、氧化应激和细胞凋亡的信号通路变化一致。这些数据表明姜黄素及其衍生物可能是改善恰加斯心脏病的合适药物。
Trypanosoma cruzi, the etiologic agent of Chagas disease, causes an acute myocarditis and chronic cardiomyopathy. The current therapeutic agents for this disease are not always effective and often have severe side effects. Curcumin, a plant polyphenol, has demonstrated a wide range of potential therapeutic effects. In this study, we examined the effect of curcumin on T. cruzi infection in vitro and in vivo. Curcumin pretreatment of fibroblasts inhibited parasite invasion. Treatment reduced the expression of the low density lipoprotein receptor, which is involved in T. cruzi host cell invasion. Curcumin treatment of T. cruzi-infected CD1 mice reduced parasitemia and decreased the parasitism of infected heart tissue. This was associated with a significant reduction in macrophage infiltration and inflammation in both the heart and liver; moreover, curcumin-treated infected mice displayed a 100% survival rate in contrast to the 60% survival rate commonly observed in untreated infected mice. These data are consistent with curcumin modulating infection-induced changes in signaling pathways involved in inflammation, oxidative stress, and apoptosis. These data suggest that curcumin and its derivatives could be a suitable drug for the amelioration of chagasic heart disease.
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影响因子：
7.3
作者：
Chuenkova, Marina V.;PereiraPerrin, Mercio
通讯作者：
PereiraPerrin, Mercio
影响因子：
3.8
作者：
Nagajyothi F;Weiss LM;Silver DL;Desruisseaux MS;Scherer PE;Herz J;Tanowitz HB
通讯作者：
Tanowitz HB
影响因子：
4.7
作者：
Hong, JI;Bose, M;Yang, CS
通讯作者：
Yang, CS
影响因子：
6.4
作者：
Salazar Gutierrez, Fredy Roberto;Lalu, Manoj Mathew;Silva, Joao Santana
通讯作者：
Silva, Joao Santana
DOI：
10.1152/ajpheart.00154.2010
发表时间：
2010-10-01
影响因子：
4.8
作者：
Ghosh, Siddhartha S.;Salloum, Fadi N.;Kukreja, Rakesh C.
通讯作者：
Kukreja, Rakesh C.