Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis.
Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis.
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内皮功能障碍和炎症：类风湿关节炎的免疫
DOI：
10.1155/2016/6813016
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发表时间：
2016
影响因子：
4.6
通讯作者：
Wei W
中科院分区：
文献类型：
--
作者：
Yang X;Chang Y;Wei W
炎症作为类风湿性关节炎（RA）的特征，导致内皮细胞（EC）的活化。激活的内皮细胞通过增加白细胞粘附分子的表达诱导动脉粥样硬化。内皮功能障碍（艾德）是指内皮细胞修复机制的失效。它也是动脉粥样硬化的早期临床前标志物，常见于RA患者。RA现已被确定为一个独立的心血管危险因素，而RA中艾德的机制决定因素仍然知之甚少。越来越多的研究表明，RA部位的EC既是炎症过程的积极参与者，也是炎症过程的调节者。在过去的十年中，内皮功能障碍在RA中的作用与心血管疾病（CVD）有关。与此同时，针对这一现象的几种维持药物已经进行了测试，取得了可喜的成果。内皮功能的评估可能是一个有用的工具，以识别和监测RA患者。
Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs). Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules. Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms. It is also an early preclinical marker of atherosclerosis and is commonly found in RA patients. RA is now established as an independent cardiovascular risk factor, while mechanistic determinants of ED in RA are still poorly understood. An expanding body of study has shown that EC at a site of RA is both active participant and regulator of inflammatory process. Over the last decade, a role for endothelial dysfunction in RA associated with cardiovascular disease (CVD) has been hypothesized. At the same time, several maintenance drugs targeting this phenomenon have been tested, which has promising results. Assessment of endothelial function may be a useful tool to identify and monitor RA patients.