Serum Cardiac Troponin I is a Candidate Biomarker for Cardiomyopathy in Duchenne and Becker Muscular Dystrophies
Serum Cardiac Troponin I is a Candidate Biomarker for Cardiomyopathy in Duchenne and Becker Muscular Dystrophies
复制标题
血清心肌肌钙蛋白 I 是杜兴肌营养不良症和贝克肌营养不良症心肌病的候选生物标志物
DOI：
10.1002/mus.27522
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发表时间：
2022
期刊：
影响因子：
3.4
通讯作者：
Kazumoto Iijima
中科院分区：
文献类型：
--
作者：
Hiroshi Yamaguchi ;Hiroyuki Awano;Tetsushi Yamamoto;Yoshinori Nambu;Kazumoto Iijima
Introduction/AimsSerum cardiac troponin I (cTnI), its relation to cardiomyopathy, and the contribution of theACTN3genotype to serum levels of cTnI in Duchenne and Becker muscular dystrophy (DMD and BMD, respectively) remain unknown. In this study we aimed to reveal the characteristics of cTnI, assess whether cTnI is a biomarker for cardiomyopathy in these dystrophinopathies, and evaluate the contribution of theACTN3genotype to the serum levels of cTnI in DMD patients.MethodsSerum cTnI values obtained from 127 DMD and 47 BMD patients were analyzed retrospectively. The relationship between cTnI and echocardiography data or theACTN3XX genotype was assessed.ResultsThe cTnI levels and proportion of patients with abnormal cTnI levels were significantly higher among DMD patients than BMD, especially in the second decade of life. In DMD, the cTnI level reached a maximum at 13 years, and left ventricular ejection fraction (LVEF) became abnormal approximately 1 year subsequently. In BMD, the cTnI level peaked at the age of 14 years, and LVEF became abnormal 3 years later. Decreased LVEF was observed after cTnI elevation in both populations. cTnI levels by age in DMD patients with theACTN3XX genotype tended to increase significantly and early.DiscussionMyocardial injury indicated by cTnI elevation was more common and severe in DMD patients. cTnI elevation preceding cardiac dysfunction may represent an early phase of cardiomyopathy progression and may be a biomarker for early detection of cardiomyopathy in these dystrophinopathies. TheACTN3XX genotype may be a risk factor for early myocardial injury.
