Hydrophobicity-driven folding and seeded polymerization of cystine-based dimeric diamides in aqueous media
Hydrophobicity-driven folding and seeded polymerization of cystine-based dimeric diamides in aqueous media
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DOI：
10.1039/d0cc05255h
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发表时间：
2020-11-04
影响因子：
4.9
通讯作者：
Yamaguchi, Shigehiro
中科院分区：
文献类型：
--
作者：
Fukaya, Natsumi;Ogi, Soichiro;Yamaguchi, Shigehiro
以C端和n端为芳香取代基的半胱氨酸二聚体在水介质中实现了种子超分子聚合。理论和光谱研究表明，末端基团通过形成折叠构象和引导聚集状态下的分子排列，在减缓自发组装方面起着至关重要的作用。
Seeded supramolecular polymerization of cystine-based dimeric diamides with aromatic substituents at the C- and N-termini was achieved in aqueous media. Theoretical and spectroscopic studies reveal that the terminal groups play crucial roles in slowing spontaneous assembly through formation of a folded conformation and guiding molecular alignment in the aggregated state.