Recent advances in understanding Japanese encephalitis.
Recent advances in understanding Japanese encephalitis.
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DOI：
10.12688/f1000research.19693.1
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Tripathi, Aarti
中科院分区：
文献类型：
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作者：
Banerjee, Arup;Tripathi, Aarti
流行性乙型脑炎（JE）是由乙脑病毒（JEV）引起的脑炎症的临床表现。这种病毒造成永久性神经损伤，从而给公共卫生和社会带来沉重负担。神经炎症是JEV感染的标志。长时间的促炎反应主要是由于小胶质细胞激活，最终导致严重的脑炎。科学界正在不断努力了解参与JEV神经侵袭和炎症过程的细胞和分子因素。本文综述了近年来对病毒结构和致病机制的研究进展，并简要讨论了尚未解决的关键问题。我们还强调了具有挑战性的研究领域，这些领域可能为控制病毒诱导的神经炎症开辟新的途径。
Japanese encephalitis (JE) is a clinical manifestation of the brain inflammation caused by JE virus (JEV). This virus imparts permanent neurological damage, thus imposing a heavy burden on public health and society. Neuro-inflammation is the hallmark of JEV infection. The prolonged pro-inflammatory response is due primarily to microglial activation, which eventually leads to severe encephalitis. A continual effort is going on in the scientific community toward an understanding of cellular and molecular factors that are involved in JEV neuro-invasion and inflammatory processes. This review not only gives a comprehensive update on the recent advances on understanding virus structure and mechanisms of pathogenesis but also briefly discusses crucial unresolved issues. We also highlight challenging areas of research that might open new avenues for controlling virus-induced neuro-inflammation.