RELATION BETWEEN LUNG VOLUME AND PULMONARY VASCULAR RESISTANCE
RELATION BETWEEN LUNG VOLUME AND PULMONARY VASCULAR RESISTANCE
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DOI：
10.1161/01.res.9.2.465
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发表时间：
1961-01-01
影响因子：
20.1
通讯作者：
OREILLY, RJ
中科院分区：
文献类型：
--
作者：
SIMMONS, DH;MILLER, JH;OREILLY, RJ
本研究对麻醉犬进行了10项实验。在潮汐量、呼吸速率、动脉pH和PCO2保持不变的情况下，通过使用负、零或正呼气末压来改变肺容量，导致肺容量的平均变化为- 32%、0%和+75%。肺血管阻力随肺体积减小或增大而增大，肺血管阻力与肺体积呈u型曲线关系。由于在这些手术过程中，大肺血管的跨壁扩张压力增加或保持不变，PVR的变化不能归因于系统循环动力学的变化，如心输出量。值得注意的是，如先前报道的，心输出量随呼气末负压（有效的负压呼吸）而增加，随呼气末正压（有效的正压呼吸）而减少。提出了一个假设来解释有关阻力和肺体积的u形曲线。
Ten experiments were conducted on anesthetized dogs ventilated with a Starling pump and breathing O2. While tidal volume, respiratory rate and arterial pH and PCO2 were kept constant, lung volume was varied by using either a negative, zero, or positive end-expiratory pressure, leading to average changes in lung volume of -32, 0, and +75%. Pulmonary vascular resistance increased with either decreased or increased lung volume, indicating that the relationship between resistance and lung volume is a U-shaped curve. Since the transmural distending pressures of large pulmonary vessels either increased or remained unchanged during these procedures, changes in PVR cannot be ascribed to changes in systemic circulatory dynamics, such as cardiac output. It was noted that cardiac output increased with negative end-expiratory pressure (effectively, negative-pressure breathing) and decreased with positive end-expiratory pressures (effectively, positive-pressure breathing), as previously reported. A hypothesis is presented for explaining the U-shaped curve relating resistance and lung volume.