The ultrarapid and the transient outward K+ current in human atrial fibrillation.: Their possible role in postoperative atrial fibrillation
The ultrarapid and the transient outward K+ current in human atrial fibrillation.: Their possible role in postoperative atrial fibrillation
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DOI：
10.1006/jmcc.2000.1221
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发表时间：
2000-10-01
影响因子：
5
通讯作者：
Beuckelmann, DJ
中科院分区：
文献类型：
--
作者：
Brandt, MC;Priebe, L;Beuckelmann, DJ
M. C.布兰特湖普里耶贝波尔。M. Sudkamp和D. J. Beuckelmann。心房颤动时的超快速和瞬时钾电流他们在术后房颤中的可能作用。分子和细胞心脏病学杂志（2000）32，1885-1896。心房颤动（AF）引起心房传导的明显变化，其特征在于电重构。在这个过程中的特定的K+外向电流的改变可能的意义的实验数据仍然是有限的，在人类AF。超快速延迟整流电流（I-Kur）尚未在AF研究其敏感性4-氨基吡啶（4-AP）。为了阐明（1）4-AP敏感的I-Kur电流（与不使用4-AP的记录相比，I-Kur*）和（2）瞬时外向电流（I-to）在与AF相关的心房复极变化中的作用，从接受择期心脏手术的患者的心房肌细胞获得全细胞电压钳记录，这些患者有和没有心房颤动（AF/非AF）病史。此外，实验数据和术后AF之间的可能关系进行了研究。在AF患者中，I-Kur*.在+50 mV时，降低了40% [5.00 +/- 0.32 pA/pF（非AF）和2.91 +/- 0.45 pA/pF（AF），P
M. C. BRANDT, L. PRIEBE, T. BOHLE. M. SUDKAMP AND D. J. BEUCKELMANN. The Ultrarapid and the Transient Outward K+ Current in Human Atrial Fibrillation. Their Possible Role in Postoperative Atrial Fibrillation. Journal of Molecular and Cellular Cardiology (2000) 32, 1885-1896. Atrial fibrillation (AF) causes distinct changes in atrial conduction, characterized as electrical remodeling. Experimental data on the possible significance of alterations of specific K+ outward currents in this process are still limited in human AF. The ultra-rapid delayed rectifier current (I-Kur) has not been studied in AF with respect to its sensitivity to 4-Aminopyridine (4-AP). To clarify the role of (1) the 4-AP sensitive I-Kur current, compared to recordings without using 4-AP (I-Kur*), and (2) the transient outward current (I-to) in changes of atrial repolarizarion associated with AF, whole cell voltage-clamp recordings were obtained from atrial myocytes of patients undergoing elective cardiac surgery, with and without a history of atrial fibrillation (AF/non-AF). Further, a possible relation between experimental data and postoperative AF was studied. In AF patients, I-Kur*. was reduced by 40% [5.00 +/- 0.32 pA/pF (non-AF) and 2.91 +/- 0.45 pA/pF (AF) at + 50 mV, P