Association between circulating tumor necrosis factor receptors and oral bacterium in patients receiving hemodialysis: a cross-sectional study
Association between circulating tumor necrosis factor receptors and oral bacterium in patients receiving hemodialysis: a cross-sectional study
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DOI：
10.1007/s10157-020-01952-2
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发表时间：
2020-08-20
影响因子：
2.3
通讯作者：
Iwata, Takanori
中科院分区：
文献类型：
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作者：
Mikami, Risako;Mizutani, Koji;Iwata, Takanori
背景 高水平的肿瘤坏死因子 (TNF) 受体（TNFR、TNFR1 和 TNFR2）是炎症标志物，据报道是血液透析患者死亡率的重要预测因素。牙龈卟啉单胞菌是牙周炎的主要致病菌，可诱发全身炎症。我们研究了 P 丰度之间的关联。血液透析患者唾液牙龈素和血清 TNFR 水平。方法 对东京都市区一家诊所就诊的 121 名血液透析患者进行横断面研究。医疗访谈和检查、综合牙科检查、细菌检查。牙龈素唾液，并测量循环 TNFR 水平。进行多元线性回归分析以评估P数量之间的关联。牙龈和循环 TNFR 水平。结果 TNFR1、TNFR2与高敏C反应蛋白（hsCRP）呈正相关。重度牙周炎与P的数量显着相关。唾液牙龈素水平，但不是血清 TNFR 水平。 P 的数量。在调整年龄、性别、体重指数、吸烟状况、糖尿病史、既往心血管疾病事件、血清 hsCRP 和白蛋白水平以及牙周炎严重程度后，牙龈炎与血清中 TNFR1 和 TNFR2 水平显着相关[TNFR1：系数 0.76，95% 置信区间 (CI) 0.14-1.37，p = 0.02；对于 TNFR2：系数 0.95，95% CI 0.09-1.80，p = 0.03]。结论循环中TNFR水平与P的数量相关。调整相关临床因素后的牙龈素唾液。
Background High levels of tumor necrosis factor (TNF) receptors (TNFRs; TNFR1 and TNFR2), markers of inflammation, have been reported as significant predictors of mortality in hemodialysis patients.Porphyromonas gingivalisis a major pathogenic bacterium involved in periodontitis, which induces systemic inflammation. We investigated the association between the abundance ofP. gingivalisin saliva and serum TNFR levels in hemodialysis patients. Methods A cross-sectional study was conducted on 121 hemodialysis patients visiting a clinic in the Tokyo metropolitan area. Medical interviews and examinations, comprehensive dental examinations, bacterial examinations forP. gingivalisin saliva, and measurements of circulating TNFR levels were conducted. Multiple linear regression analysis was performed to evaluate the association between the number ofP. gingivalisand circulating TNFR levels. Results TNFR1 and TNFR2 were positively correlated with high-sensitivity C-reactive protein (hsCRP). Severe periodontitis was significantly associated with the number ofP. gingivalisin saliva but not serum TNFR levels. The number ofP. gingivaliswas significantly associated with both TNFR1 and TNFR2 levels in sera after adjusting for age, sex, body mass index, smoking status, history of diabetes, prior cardiovascular disease events, serum levels of hsCRP and albumin, and severity of periodontitis [for TNFR1: coefficient 0.76, 95% confidence interval (CI) 0.14-1.37,p = 0.02; for TNFR2: coefficient 0.95, 95% CI 0.09-1.80,p = 0.03]. Conclusion Circulating TNFR levels are associated with the number ofP. gingivalisin saliva after adjusting for relevant clinical factors.