Toll-like receptors and ischemic brain injury.
Toll-like receptors and ischemic brain injury.
复制标题
DOI：
10.1097/nen.0000000000000068
复制
发表时间：
2014-05
影响因子：
3.2
通讯作者：
Stenzel-Poore MP
中科院分区：
文献类型：
--
作者：
Gesuete R;Kohama SG;Stenzel-Poore MP
Toll样受体（TLR）是先天免疫的主要调节因子，在感染期间炎症反应的激活中起着不可或缺的作用。此外，TLR影响身体对多种形式损伤的反应。最近的研究表明，TLR在脑卒中后缺血性脑损伤中起着调节作用。有趣的是，它们在缺血前的刺激诱导了一种具有神经保护作用的耐受状态。这种现象被称为TLR预处理，是TLR对缺血性损伤的反应重新编程的结果。本文就TLRs在脑缺血中的作用及预处理中内源性神经保护通路的激活作一综述。我们强调了干扰素相关反应的保护作用和TLR预处理涉及血脑屏障的潜在作用部位。药理学调节TLR激活以促进对中风的保护是开发针对缺血性脑损伤的预防性和急性治疗的有前途的方法。
Toll-like receptors (TLRs) are master regulators of innate immunity and play an integral role in the activation of the inflammatory response during infections. In addition, TLRs influence the body’s response to numerous forms of injury. Recent data have shown that TLRs play a modulating role in ischemic brain damage after stroke. Interestingly, their stimulation prior to ischemia induces a tolerant state that is neuroprotective. This phenomenon, referred to as TLR preconditioning, is the result of reprogramming of the TLR response to ischemic injury. This review addresses the role of TLRs in brain ischemia and the activation of endogenous neuroprotective pathways in the setting of preconditioning. We highlight the protective role of the interferon-related response and the potential site of action for TLR preconditioning involving the blood-brain-barrier. Pharmacological modulation of TLR activation to promote protection against stroke is a promising approach for the development of prophylactic and acute therapies targeting ischemic brain injury.
影响因子：
3.3
作者：
Pappas, D. J.;Gabatto, P. A.;Oksenberg, D.;Khankhanian, P.;Baranzini, S. E.;Gan, L.;Oksenberg, J. R.
通讯作者：
Oksenberg, J. R.