EXPRESSION OF GROWTH-FACTOR PEPTIDES AND THEIR RECEPTORS IN NEUROENDOCRINE TUMORS OF THE DIGESTIVE-SYSTEM
EXPRESSION OF GROWTH-FACTOR PEPTIDES AND THEIR RECEPTORS IN NEUROENDOCRINE TUMORS OF THE DIGESTIVE-SYSTEM
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DOI：
10.3109/02841869309083898
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发表时间：
1993-01-01
期刊：
影响因子：
3.1
通讯作者：
OBERG, K
中科院分区：
文献类型：
--
作者：
CHAUDHRY, A;FUNA, K;OBERG, K
消化系统的神经内分泌肿瘤是一种生长缓慢的肿瘤，通常在肿瘤细胞周围和腹膜腔内表现出明显的纤维化。本文应用免疫组织化学和原位杂交技术检测了30例中肠类癌和胰腺内分泌肿瘤中肽生长因子及其受体的表达。我们的数据表明，这些肿瘤表达多肽生长因子、PDGF、转化生长因子-β和碱性成纤维细胞生长因子。PDGF在70%的组织中表达于肿瘤细胞和间质。PDGFα受体见于肿瘤细胞群，偶见于邻近间质，而PDGFβ受体仅见于间质。我们的数据提示，PDGF可能通过旁分泌和可能的自分泌机制参与对肿瘤细胞的自分泌刺激和刺激基质细胞的生长。此外，肿瘤组织在超过一半的检查组织中表达所有三种异构体的转化生长因子-β。肿瘤细胞产生小的潜伏复合体，通过旁分泌机制逃避转化生长因子-β的强烈抑制作用，刺激基质细胞生长和基质沉积。碱性成纤维细胞生长因子是一种强有力的内皮细胞生长刺激因子，所有被检测的肿瘤组织都有表达。我们的数据表明，多肽生长因子可能在肿瘤进展和伴随这些肿瘤的促结缔组织生长反应中发挥重要作用。
Neuroendocrine tumors of the digestive system are slow growing neoplasms which often present with pronounced fibrosis around tumor cells and in the peritoneal cavity. In this report 30 midgut carcinoids and endocrine pancreatic tumors were examined for the expression of peptide growth factors and their receptors, both by immunohistochemistry and in situ hybridization. Our data indicate that mulitple peptide growth factors, PDGF, TGF-beta, and bFGF are expressed by these tumors. PDGF was expressed on tumor cells and stroma in 70% of tissues examined. PDGF alpha-receptor was seen on clusters of tumor cells and occassionally on adjacent stroma, whereas PDGF beta-receptor was seen only in the stroma. Our data suggest that PDGF may be involved in the autocrine stimulation of tumor cells and stimulation of stromal cell growth through paracrine and possibly autocrine mechanism. In addition, tumor tissues express all three isoforms of TGF-beta in more than half of the tissues examined. Tumor cells produce small latent complexes causing an escape from potent inhibitory effect of TGF-beta and stimulation of stromal cell growth and matrix deposition through paracrine mechanism. bFGF, a potent stimulant of endothelial cell growth, was expressed by all tumor tissues examined. Our data suggest that multiple peptide growth factors may have an important role in tumor progression and desmoplastic reaction accompanying these tumors.