Protein-kinase C: its role in activity-dependent Purkinje cell dendritic development and plasticity
Protein-kinase C: its role in activity-dependent Purkinje cell dendritic development and plasticity
复制标题
DOI：
10.1080/14734220310016150
复制
发表时间：
2003-01-01
期刊：
影响因子：
3.5
通讯作者：
Kapfhammer, JP
中科院分区：
文献类型：
--
作者：
Metzger, F;Kapfhammer, JP
小脑是控制运动学习和表现的中枢器官。在这方面，细胞可塑性模型系统的多攀登纤维消除和长期抑郁症已被深入研究。这些塑料变化中涉及的信号通路现在在分子水平上得到了很好的理解，蛋白激酶C（PKC）活性似乎在这两个过程中起着至关重要的作用。此外，最近的研究表明，浦肯野细胞树突状细胞的发育也严重依赖于PKC的活性。因此，Ca2+依赖的PKC亚型，通过代谢型谷氨酸受体的突触输入激活，触发功能的变化，以及长期解剖成熟的浦肯野细胞树突状树在小脑发育过程中在不同的时间水平。本文综述了这些发现，并提出了一个假说的联系的功能机制，潜在的LTD和浦肯野细胞树突的分化。
The cerebellum is a central organ in the control of motor learning and performance. In this respect, the cellular plasticity model systems of multiple climbing fiber elimination and long-term depression have been intensively studied. The signalling pathways involved in these plastic changes are now well understood on a molecular level and protein kinase C (PKC) activity appears to be crucially involved in both processes. Furthermore, as shown in recent studies, Purkinje cell dendritic development also critically depends on the activity of PKC. Thereby, the Ca2+-dependent PKC subtypes, activated by synaptic inputs through metabotropic glutamate receptors, trigger functional changes as well as long-term anatomical maturation of the Purkinje cell dendritic tree during cerebellar development at different time levels. This review summarizes these findings and forwards the hypothesis of a link between the functional mechanisms underlying LTD and the differentiation of Purkinje cell dendrites.