In vitro vinblastine-induced tubulin paracrystals.
In vitro vinblastine-induced tubulin paracrystals.
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DOI：
10.1016/s0021-9258(18)34031-6
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发表时间：
1982-09
期刊：
影响因子：
--
通讯作者：
G. Na;S. N. Timasheff
中科院分区：
文献类型：
--
作者：
G. Na;S. N. Timasheff
纯化的小牛脑微管蛋白在体外被抗癌药物长春碱诱导自聚集成类晶体结构。这些微管蛋白-长春碱类晶体的大小、形状、光学双折射和药物化学计量与体内形成的类晶体相似。长春新碱和脱乙酰长春碱可以形成类似的结构，但秋水仙碱或鬼臼毒素不能。
Purified calf brain tubulin has been induced to self-aggregate in vitro into paracrystalline structures by the anti-cancer drug vinblastine. The size, shape, optical birefringence, and drug stoichiometry of these tubulin-vinblastine paracrystals are similar to those of paracrystals formed in vivo. Similar structures can be formed with vincristine and desacetylvinblastine, but not with colchicine or podophyllotoxin.