MORPHOGENESIS OF DUCTAL NETWORKS IN THE MOUSE PROSTATE
MORPHOGENESIS OF DUCTAL NETWORKS IN THE MOUSE PROSTATE
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DOI：
10.1095/biolreprod34.5.961
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发表时间：
1986-06-01
影响因子：
3.6
通讯作者：
DONJACOUR, AA
中科院分区：
文献类型：
--
作者：
SUGIMURA, Y;CUNHA, GR;DONJACOUR, AA
通过显微解剖技术研究了小鼠前列腺腹侧叶和背外侧叶（VP和DLP）腺性结构的出生后生长和发育，该技术能够精确量化从尿道发出的初级导管数量、末端导管尖端以及导管分支点。出生时，VP的左右叶均由1 - 3条已经经历了二级和三级分支的主导管组成。相比之下，出生时更为复杂的DLP在左右两侧每个叶都有9 - 12条未分支的主导管。在出生后的前15天，成年腺体80.7%的尖端和76.4%的分支点在VP中形成，70.4%的尖端和53.6%的分支点在DLP中形成。导管分支在60到90天完成。DLP的发育分为三个阶段：首先，形成未分支的主导管（前10天）；其次，每条主导管远端分支，导致每条主导管有3 - 5个末端分支（出生后10 - 15天）；第三，30天龄后远端导管内导管黏膜内褶的细化。前列腺外侧叶（LP）是DLP的腹外侧分支，在出生后1到5天之间开始分支形态发生。LP生长进入并嵌入VP的包膜内，这可以解释为什么这两个叶的导管结构相似。小鼠VP和DLP在器官发生和形态上这些迄今未被认识到的差异，以及小鼠前列腺叶之间和叶内显著的形态异质性，可能是前列腺内功能异质性的形态表现。
Postnatal growth and development of the glandular architecture of the ventral and dorsolateral lobes of the mouse prostate (VP and DLP) were investigated by microdissection techniques that permitted precise quantification of the numbers of primary ducts emerging from the urethra, the terminal ductal tips, and ductal branchpoints. At birth both the right and left lobe of the VP consisted of 1-3 main ducts that had already undergone secondary and tertiary branching. In contrast, at birth the more complex DLP had 9-12 unbranched main ducts per lobe on both the right and left sides. During the first 15 days after birth, 80.7% of tips and 76.4% of branchpoints of the adult gland formed in the VP, and 70.4% of tips and 53.6% of branch-points formed in the DLP. Ductal branching was completed by 60 to 90 days. The DLP developed in three stages: first, formation of unbranched main ducts (first 10 days); second, distal branching of each main duct resulting in 3-5 terminal branches per main duct (10-15 days after birth); third, elaboration of intraductal mucosal infolding in distal ducts after 30 days of age. Ducts of the lateral prostate (LP), a ventrolateral subdivision of the DLP, initiated branching morphogenesis between 1 to 5 days after birth. The LP grew into and became embedded within the capsule of the VP, which may explain why the ductal architecture of these two lobes are similar. These heretofore unrecognized differences in the organogenesis and morphology of the mouse VP and DLP and the striking morphological heterogeneity both between and within the lobes of the mouse prostate may be morphological manifestation of functional heterogeneities within the prostate.