CD30+ large B cell lymphoma with anaplastic features and complete loss of B cell marker expression arising from follicular lymphoma.
CD30+ large B cell lymphoma with anaplastic features and complete loss of B cell marker expression arising from follicular lymphoma.
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CD30 大 B 细胞淋巴瘤具有间变性特征，且滤泡性淋巴瘤引起的 B 细胞标志物表达完全丧失。
DOI：
10.1111/his.13919
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发表时间：
2019
期刊：
影响因子：
6.4
通讯作者：
Jaffe,ElaineS
中科院分区：
文献类型：
--
作者：
Raess,PhilippW;Wang,Hao-Wei;Pack,SvetlanaD;Jaffe,ElaineS
滤泡性淋巴瘤是最常见的惰性 B 细胞淋巴瘤，占所有非霍奇金淋巴瘤的 20%1。滤泡性淋巴瘤转化为更具侵袭性的淋巴瘤是一种明显的现象，30% 的病例在诊断后 10 年内会发生这种现象2。滤泡性淋巴瘤最常转化为弥漫性大 B 细胞淋巴瘤。向保留 B 细胞转录程序免疫表型标记表达的其他肿瘤（伯基特淋巴瘤、B 淋巴细胞白血病/淋巴瘤、经典霍奇金淋巴瘤）的转化也有详细描述3-7。滤泡性淋巴瘤也可以转化为组织细胞/树突状细胞肿瘤，这表明谱系不忠是可能的8-10。存在 CD30 表达和间变性形态的转化滤泡性淋巴瘤的罕见报道，但所有先前描述的病例均保留一种或多种 B 细胞谱系特异性标记物的表达 11, 12。
Follicular lymphoma is the most common indolent B cell lymphoma, accounting for 20% of all non-Hodgkin lymphomas1. Transformation of follicular lymphoma to a more aggressive lymphoma is a well-characterized phenomenon that occurs in 30% of cases at 10 years following diagnosis2.Follicular lymphoma most frequently transforms to diffuse large B cell lymphoma. Transformation to other neoplasms that retain expression of immunophenotypic markers of the B cell transcriptional program (Burkitt lymphoma, B lymphoblastic leukemia/lymphoma, classical Hodgkin lymphoma) is also well-described3–7. Follicular lymphoma can also transform into histiocytic/dendritic cell tumors, demonstrating that lineage infidelity is possible8–10. Rare reports of transformed follicular lymphoma with CD30 expression and anaplastic morphology exist, but all previously described cases retain expression of one or more B cell lineage-specific markers11, 12.