Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine withdrawal-induced place conditioning.
Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine withdrawal-induced place conditioning.
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急性或慢性帕罗西汀和氟伏沙明对吗啡戒断引起的位置调节的作用对比。
DOI：
10.1016/0014-2999(94)00770-8
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发表时间：
1995
影响因子：
5
通讯作者：
R. Sewell
中科院分区：
文献类型：
--
作者：
M. Rafieian;A. Gray;P. Spencer;R. Sewell
研究了帕罗西汀和氟伏沙明对吗啡依赖大鼠纳洛酮戒断引起的地方厌恶的急性和慢性影响。急性给予氟伏沙明（在纳洛酮戒断配对前 30 分钟皮下给予 25 mg/kg）和长期每日帕罗西汀（10 mg/kg 皮下注射）与吗啡诱导方案共同给药，两者均减弱吗啡戒断场所厌恶。相反，急性给予帕罗西汀（皮下注射高达 25 mg/kg）或长期每日氟伏沙明（皮下注射 10 mg/kg）与吗啡共同给药不会改变随后的戒断场所厌恶。先前的放射性配体结合研究表明氟伏沙明具有阿片类药物置换特性。因此，有人认为，急性氟伏沙明可能通过血清素以及部分通过类阿片机制降低戒断厌恶，而慢性帕罗西汀通过血清素能机制降低戒断厌恶，但尚不清楚阿片类系统是否在帕罗西汀的作用中发挥任何作用。
The acute and chronic effects of paroxetine and fluvoxamine on naloxone withdrawal-induced place aversion in morphine dependent rats were investigated. Acutely administered fluvoxamine (25 mg/kg s.c. given 30 min prior to naloxone withdrawal pairing) and chronic daily paroxetine (10 mg/kg s.c.) coadministration with a morphine induction protocol, both attenuated morphine withdrawal place aversion. Conversely, acutely administered paroxetine (up to 25 mg/kg s.c.) or chronic daily fluvoxamine (10 mg/kg s.c.) coadministration with morphine did not modify subsequent withdrawal place aversion. Previous radioligand binding studies indicate that fluvoxamine has opioid-displacing properties. It is suggested therefore that acute fluvoxamine may have decreased withdrawal aversion, probably through serotonin and also, in part, via an opioid-like mechanism whereas chronic paroxetine decreased withdrawal aversion by a serotonergic mechanism, but it is not clear whether opioid systems play any role in the action of paroxetine.