Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP‐1
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP‐1
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Lin28通过SREBP‐1增强脂肪酸从头合成促进癌症进展
DOI：
10.15252/embr.201948115
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发表时间：
2019-10
期刊：
影响因子：
7.7
通讯作者：
Yang Zhang;Chenchen Li;Chuan-Zhen Hu;Qian Wu;Yongping Cai;Songge Xing;Hui Lu;Lin Wang;De H
中科院分区：
文献类型：
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作者：
Yang Zhang;Chenchen Li;Chuan-Zhen Hu;Qian Wu;Yongping Cai;Songge Xing;Hui Lu;Lin Wang;De H
Lin28 plays an important role in promoting tumor development, whereas its exact functions and underlying mechanisms are largely unknown. Here, we show that both human homologs of Lin28 accelerate de novo fatty acid synthesis and promote the conversion from saturated to unsaturated fatty acids via the regulation of SREBP‐1. By directly binding to the mRNAs of both SREBP‐1 and SCAP, Lin28A/B enhance the translation and maturation of SREBP‐1, and protect cancer cells from lipotoxicity. Lin28A/B‐stimulated tumor growth is abrogated by SREBP‐1 inhibition and by the impairment of the RNA binding properties of Lin28A/B, respectively. Collectively, our findings uncover that post‐transcriptional regulation by Lin28A/B enhances de novo fatty acid synthesis and metabolic conversion of saturated and unsaturated fatty acids via SREBP‐1, which is critical for cancer progression.
