COVID-19 Survival and its impact on chronic kidney disease.
COVID-19 Survival and its impact on chronic kidney disease.
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DOI：
10.1016/j.trsl.2021.11.003
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Sise ME
中科院分区：
文献类型：
--
作者：
Long JD;Strohbehn I;Sawtell R;Bhattacharyya R;Sise ME
高达 87% 的 2019 年冠状病毒病 (COVID-19) 住院患者在感染后会出现慢性后遗症。在 COVID-19 大流行中，目前尚不清楚 COVID-19 感染对肾功能的长期影响。在这篇综述中，我们重点介绍了目前对 COVID-19 相关肾损伤病理生理学的理解以及 COVID-19 可能对长期肾功能的影响。 COVID-19引起的急性肾损伤可能导致肾小管损伤、内皮损伤和肾小球损伤。我们强调了大型肾活检和尸检系列的组织病理学相关性。通过对迄今为止已发表的文献进行全面回顾，我们总结了 COVID-19 相关 AKI 的恢复率。最后，我们讨论了某些遗传差异，包括 APOL1 风险等位基因（塌陷性肾小球病的危险因素），加上系统性医疗保健差异，可能如何导致少数种族和族裔群体在 COVID-19 后肾功能下降的负担过重。我们强调需要进行前瞻性研究来确定 COVID-19 后慢性肾脏疾病负担的真实发生率。
Up to 87% of patients hospitalized with coronavirus disease 2019 (COVID-19) experience chronic sequelae following infection. The long-term impact of COVID-19 infection on kidney function is largely unknown at this point in the COVID-19 pandemic. In this review, we highlight the current understanding of the pathophysiology of COVID-19-associated kidney injury and the impact COVID-19 may have on long-term kidney function. COVID-19-induced acute kidney injury may lead to tubular injury, endothelial injury, and glomerular injury. We highlight histopathologic correlates from large kidney biopsy and autopsy series. By conducting a comprehensive review of published literature to date, we summarize the rates of recovery from COVID-19-associated-AKI. Finally, we discuss how certain genetic differences, including APOL1 risk alleles (a risk factor for collapsing glomerulopathy), coupled with systemic healthcare disparities, may lead to a disproportionate burden of post-COVID-19-kidney function decline among racial and ethnic minority groups. We highlight the need for prospective studies to determine the true incidence of chronic kidney disease burden after COVID-19.
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纽约市Covid-19危重疾病患者急性肾脏损伤的发生率降低。
影响因子：
6
作者：
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影响因子：
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作者：
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DOI：
10.1056/nejmoa2109072
发表时间：
2021-10-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bergwerk M;Gonen T;Lustig Y;Amit S;Lipsitch M;Cohen C;Mandelboim M;Levin EG;Rubin C;Indenbaum V;Tal I;Zavitan M;Zuckerman N;Bar-Chaim A;Kreiss Y;Regev-Yochay G
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影响因子：
64.8
作者：
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影响因子：
2.8
作者：
Chaudhri, Imran;Moffitt, Richard;Koraishy, Farrukh M.
通讯作者：
Koraishy, Farrukh M.